Results 51 to 60 of about 4,989,124 (282)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The dynamic developmental process of adolescent non-suicidal self-injury disclosure: a qualitative study

Frontiers in Psychiatry
BackgroundNon-suicidal self-injury poses a serious threat to adolescents’ mental health, and if such behavior remains unexpressed or unshared over a long period, it may lead to further deterioration of their psychological well-being.
Zikang Liu, Zikang Liu, Ruofei Wang, Ruofei Wang, Xingxue Li, Xingxue Li, Zhe Yuan, Zhe Yuan, Tong Wu, Tong Wu, Hong Liang   +10 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

National Open Disclosure Steering Committee Terms of Reference 2022

, 2022
The HSE National Open Disclosure Steering Committee (ODSC) was established in April 2019, to strengthen corporate oversight, strategic leadership and accountability with the on-going implementation of the National Open Disclosure programme and policy*. (
HSE, National Open Disclosure Steering Committee
core  

Hubungan Persepsi Klien tentang Konseling dan Ketrampilan Komunikasi Konselor dalam Konseling dengan Pengungkapan Diri Klien

Jurnal Ilmu Pendidikan, 2016
The main purpose of this study was to examine the correlation between clients' perception of counseling, counselors' communication skills in counseling and clients' self-disclosure, as well as the differences of clients' self-disclosure in counseling in ...
Herman Nirwana
doaj   +1 more source

Japanese Young Women Did not Discriminate between Robots and Humans as Listeners for Their Self-Disclosure -Pilot Study-

Multimodal Technologies and Interaction, 2020
Disclosing personal matters to other individuals often contributes to the maintenance of our mental health and social bonding. However, in face-to-face situations, it can be difficult to prompt others to self-disclose because people often feel ...
Takahisa Uchida, Hideyuki Takahashi, Midori Ban, Jiro Shimaya, Takashi Minato, Kohei Ogawa, Yuichiro Yoshikawa, Hiroshi Ishiguro   +7 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source