Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Effects of congruence-incongruence between locus of control and field dependence on self-disclosure
, 1983 The purpose of this study was to investigate the combined effects of the two personality constructs of field dependence and locus of control on self-disclosure.
Macomber, Mary Anne
core
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
A Constructivist Grounded Theory Of Self-Disclosure In Hybrid Pastoral Care
This thesis explores the transformative dynamics of computer-mediated communication (CMC) to self-disclosure in pastoral care, a field traditionally dominated by face-to-face interactions.
Neves, Samuel
core +1 more source
The Form and Function of Self-Disclosure in Depressed Adolescents [PDF]
, 2013 Adolescent depression is a major public health concern, prevalence estimates of which indicate that from 9.5% (Costello, Mustillo, Erkanli, Keeler, & Angold, 2003) to 11.7% (Merikangas et al., 2010) of adolescents may experience at some point; these ...
McHugh, Rebecca
core
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
How motivations of SNSs use and offline social trust affect college students' self-disclosure on SNSs: An investigation in China [PDF]
Social Networking Sites (SNSs) have been proliferating and growing in popularity worldwide throughout the past few years, which have received significant interest from researchers.
Weiwei, Zhang, Peiyi, Huang
core
An Experimental Test of Processes Underlying Self-Disclosure in Computer-Mediated Communication
Cyberpsychology: Journal of Psychosocial Research on Cyberpspace, 2009 A consistent finding in computer-mediated communication (CMC) and Internet research is that, compared to face-to-face communication, CMC results in higher levels of self-disclosure.
Alexander P. Schouten +2 more
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