Results 91 to 100 of about 10,498,590 (300)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Prevalence and Patterns of Self-medication in Adults of Suburban South India: A Sequential Explanatory Mixed-method Study

Current Medical Issues
Introduction: The Ottawa charter recognizes responsible self-medication as a component of self-care, particularly in resource-limited settings. However, irresponsible self-medication can lead to adverse drug interactions, polypharmacy, and delayed ...
Annu Antony, Pravin Surendran, G. I. Sandhya, Ahalya S. Kumar, M. Gouri, Nithin Prasenan, K. Swedha, Arsha S. Pillai   +7 more
doaj   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

ECO-LITERACY: WHICH BETTER EITHER JOINING STUDY GROUP OR SELF STUDY?

Jurnal Pena Sains, 2019
Eco-literacy is one aspect that is important for students to resolve the current environmental issue and sustainable living. Eco--literacy has three dimensions of caring, practical competence, and knowledge.
Ade Suryanda
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Exploring whether (and how) self-reflection can improve practice as a teacher educator

MedEdPublish, 2018
The present essay describes a model under which a method of self-improvement of teacher-educator practice can be implemented by analyzing personal practices.
Konstantinos C. Fragkos
doaj  

STUDY ON IMPLEMENTING A MODERN AND DYNAMIC SELF DEFENSE AND SELF CONTROL SYSTEM FOR STUDENTS [PDF]

Journal of Sport and Kinetic Movement, 2017
The study herein is required for substantiating the means and methods that are available to the students against the urban violence, both at physical and mental levels.
Mihai Cristian NEGOESCU
doaj