Results 91 to 100 of about 5,354,089 (273)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

DESCUIDOS SEM GÊNERO

Margens, 2022
Este breve ensaio, ao estilo de bell hooks, retoma questões entre trabalho doméstico e institucional, tendo como elemento central a casa, a qual, em outros aspectos é nosso país e nosso planeta. O problema é atualizado para além de uma questão somente feminina a partir da psicopolítica de Byung-Chul Han, especialmente no que diz respeito aos ...
openaire   +3 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Sem margem, sem caderno

Poiésis, 2008
A desenvoltura é a expressão de uma denegação em face dos valores aos quais se recusa reconhecer a importância. É, então, uma noção essencial para pensar a arte contemporânea, pois reporta-se a um comportamento que questiona a autoridade. Nesta ótica, tento analisar aqui as conseqüências da atitude irônica de certos artistas modernos e pós-modernos ...
openaire   +2 more sources

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

DE UM BERGSONISMO SEM DURAÇÃO, SEM MEMÓRIA, SEM ÉLAN

Revista Dissertatio de Filosofia
Na defesa que Maurice Blanchot faz da consistência ontológica da experiência poéticoliterária, surge uma relação filosófica ambígua com bergsonismo. Compreender como o pensamento deHenri Bergson incide em sua teoria é imprescindível para podermos estabelecer a importância deMallarmé na constituição de uma teoria do espeço literário e encontrarmos o ...
openaire   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Internismo sem intelectualismo e sem reflexividade [PDF]

Kriterion: Revista de Filosofia, 2014
Em seu livro, "Perception as a Capacity for Knowledge" (2011), John McDowell defende que a garantia fornecida pela percepção é infalível. Para tanto, é preciso entender o papel que a razão tem na constituição de estados perceptivos genuínos. Por meio dela, posicionamos estes estados no espaço lógico das razões.
openaire   +4 more sources

Investigation and modelling prediction on surface roughness of titanium in dry turning operation [PDF]

, 2009
Surface roughness basically known as Ra is one of the best important requirements in machining process. Titanium generally used for part requiring greatest reliability, therefore surface integrity must be maintained.
Elie Sem, Semilin
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