Results 81 to 90 of about 2,717,459 (291)
, 2016 Steve questiona a composição musical de maneira radical: ele quer uma música que seja criada sem um compositor, ou quase istoEnsino Médio ...
Rocha de Oliveira, Samuel +4 more
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
, 2012 Steve questiona a composição musical de maneira radical: ele quer uma música que seja criada sem um compositor, ou quase istoEnsino Médio ...
Rocha de Oliveira, Samuel +4 more
core +1 more source
VerbumO presente artigo propõe uma análise discursiva do termo ficante e de suas formulações correlatas no discurso amoroso contemporâneo, especialmente nas redes sociais digitais. Partindo do referencial teórico da Análise do Discurso de linha francesa, conforme desenvolvida por Michel Pêcheux e aprofundada por Dominique Maingueneau, investiga-se como ...
openaire +1 more source
, 2002 Image Type: SEM Image, Scale Bar: 200um, Magnification: 170, Etch: No etching, Coating: Au/Pd, Instrument Location: UNM, Scan: med, Spot Sz ...
Melim, L., Spilde, M., Northup, D.
core
4-Trifloxy-9-SEM-β-Carboline: Preparation and Synthetic Utility
, 2016 4-Trifloxy-9-SEM-β-Carboline: Preparation and Synthetic ...
Carl A. Busacca (1434076) +5 more
core +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Repeat of q16-1-27.tif, the film shrank under the SEM beam
, 2006 Image Type: SEM Image, Scale Bar: 5um, Magnification: 7000, Etch: No etching, Coating: Au/Pd, Instrument Location: UNM, kV: 15, Spot Sz ...
Melim, L., Spilde, M., Northup, D.
core