Results 81 to 90 of about 2,243,617 (302)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Repeat of q16-1-27.tif, the film shrank under the SEM beam

, 2006
Image Type: SEM Image, Scale Bar: 5um, Magnification: 7000, Etch: No etching, Coating: Au/Pd, Instrument Location: UNM, kV: 15, Spot Sz ...
Melim, L., Spilde, M., Northup, D.
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Música quase sem compositor

, 2012
Steve questiona a composição musical de maneira radical: ele quer uma música que seja criada sem um compositor, ou quase istoEnsino Médio ...
Rocha de Oliveira, Samuel, Camarneiro, Fabio, Universidade Estadual de Campinas - Unicamp - Matemática, Projeto Condigital MEC - MCT, Maia e Jonatas Manzoli, Adolfo   +4 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Música quase sem compositor

, 2016
Steve questiona a composição musical de maneira radical: ele quer uma música que seja criada sem um compositor, ou quase istoEnsino Médio ...
Rocha de Oliveira, Samuel, Camarneiro, Fabio, Universidade Estadual de Campinas - Unicamp - Matemática, Projeto Condigital MEC - MCT, Maia e Jonatas Manzoli, Adolfo   +4 more
core   +1 more source

Um estudo das formas de contabilização dos recursos econômico-financeiros em entidades sem fins lucrativos não gonervamentais [PDF]

, 2001
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Sócio-EconômicoAs entidades sem fins lucrativos não governamentais são formadas pela sociedade civil e surgem para suprir as deficiências do Estado ou para desempenhar atividades ...
Jeremias, Cristiane
core  

SEM-EDX analysis of calcium phosphate deposited by MSCs on SWNTs and MWNTs.

, 2020
The samples were observed by SEM and the localization of calcium was analyzed on (A, B) SWNTs and (C, D) MWNTs by the EDX system. A and C are low magnification images using SEM (left) and calcium mapping of the same view (right).
Gjertrud Maurstad (736185), Shinichi Kitamura (115480), Masayuki Hara (1709437), Bjørn Torger Stokke (8283213), Kenta Enomoto (8283210), Hideki Mori (1709440), Yuko Ogura (8283207)   +6 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source