Results 61 to 70 of about 2,243,617 (302)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Fotografia e arquivo: conversa com Eustáquio Neves

Manuscrítica
Conversa entre o fotógrafo mineiro Eustáquio Neves e a pesquisadora Paula Martinelli, na Mesa de Artistas do terceiro dia do 16º Congresso Internacional da APCG - Arquivo expandido: conexões e processos de criação.  
Eustáquio Neves, Paula Martinelli
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Literatura e processos de criação: conversa com Milton Hatoum

Manuscrítica
Conversa entre o escritor manauara Milton Hatoum e a pesquisadora Luz Pinheiro, na Mesa de Artistas do segundo dia do 16º Congresso Internacional da APCG - Arquivo expandido: conexões e processos de criação.  
Milton Hatoum, Luz Pinheiro
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Brugia malayi adult female head region SBF-SEM

, 2021
Posterior-anterior flythrough of Serial Block Face-SEM. 70 nm sections in anterior region of the adult female B. malayi head between the nerve ring and esophageal-intestinal boundary as viewed from the posterior end.
Mostafa Zamanian (11331993)
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

SEM of crust

, 2002
Image Type: SEM Image, Scale Bar: 200um, Magnification: 170, Etch: No etching, Coating: Au/Pd, Instrument Location: UNM, Scan: med, Spot Sz ...
Melim, L., Spilde, M., Northup, D.
core  

SEM-BSE images and SEM-EDX elemental profiling of dark stains and inclusions observed.

, 2018
7A-7B) SEM-BSE image of M36 (no bioerosion) showing bright stains and inclusions within cracks and canals. The lighter grey and white colour is evidence of higher density; 7C) Detail of infilled crack.
Malou Blank (5814893), Hege Ingjerd Hollund (5814890), Karl-Göran Sjögren (2806465)   +2 more
core   +1 more source