Results 61 to 70 of about 1,545,378 (246)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Um estudo das formas de contabilização dos recursos econômico-financeiros em entidades sem fins lucrativos não gonervamentais [PDF]
, 2001 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Sócio-EconômicoAs entidades sem fins lucrativos não governamentais são formadas pela sociedade civil e surgem para suprir as deficiências do Estado ou para desempenhar atividades ...
Jeremias, Cristiane
core
SEM-EDS results (wt%) of glassy matrix analyses.
, 2021 SEM-EDS results (wt%) of glassy matrix analyses.
Ignacio Montero-Ruiz (6576902) +4 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
SEM-EDS results (wt%) of bulk ceramic analyses.
, 2021 SEM-EDS results (wt%) of bulk ceramic analyses.
Ignacio Montero-Ruiz (6576902) +4 more
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
, 2012 Steve questiona a composição musical de maneira radical: ele quer uma música que seja criada sem um compositor, ou quase istoEnsino Médio ...
Rocha de Oliveira, Samuel +4 more
core +2 more sources
, 2002 Image Type: SEM Image, Scale Bar: 200um, Magnification: 170, Etch: No etching, Coating: Au/Pd, Instrument Location: UNM, Scan: med, Spot Sz ...
Melim, L., Spilde, M., Northup, D.
core
Gerência da largura de banda para garantir QoS adaptável em redes sem fio ad hoc [PDF]
, 2001 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico.As redes sem fio apresentam um novo paradigma computacional que tem como função principal prover aos usuários o acesso permanente à rede independente de sua localização ...
Lima, Abiel Roche
core
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source