Results 51 to 60 of about 2,243,617 (302)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Arritmias fetais. Generalidades.

Acta Médica Portuguesa, 1993
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Sem Autor
doaj   +1 more source

Applying SEM, Exploratory SEM, and Bayesian SEM to Personality Assessments

Psych
Despite the importance of demonstrating and evaluating how structural equation modeling (SEM), exploratory structural equation modeling (ESEM), and Bayesian structural equation modeling (BSEM) work simultaneously, research comparing these analytic techniques is limited with few studies conducted to systematically compare them to each other using ...
Hyeri Hong, Walter Vispoel, Alfonso Martinez   +2 more
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Guia diagnóstico de morte cerebral.

Acta Médica Portuguesa, 1998
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Sem Autor
doaj   +1 more source

SEM CHÃO, SEM TETO

Ensaios de Geografia, 2023
Este trabalho busca apresentar, por meio de imagens e mapas, os impactos da mineração de salgema no município de Maceió, capital do Estado de Alagoas. Por mais de 30 anos a extração mineral aconteceu de maneira concomitante com o crescimento urbano.
openaire   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Mensurando os impactos da abertura econômica sobre o nível de emprego: a contabilidade do crescimento no Brasil entre 1985 e 2000

Economia Aplicada, 2003
In this paper we attempt to analyze the effects of the economic opening observed in Brazil in the early 1990's, on the employment level, compared to the current environment in the 1980's, aiming to test empirically the principles ofthe Theory of ...
Herbert Vieira de Araújo, Francisco Galrão Carneiro   +1 more
doaj  

Elaboração da contabilidade: um levantamento das dificuldades encontradas em entidades sem fins lucrativos [PDF]

, 2009
TCC (Graduação) - Universidade Federal de Santa Catarina. Centro Socioeconômico. Curso de Ciências ContábeisEste trabalho teve como objetivo levantar junto às entidades sem fins lucrativos, as dificuldades encontradas para elaborar a sua contabilidade e ...
Gonçalves, Álvaro Elias
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