Results 41 to 50 of about 1,545,378 (246)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Modelling rural labor: an application to São Paulo, Brazil
Economia Aplicada, 2002 The question of modelling rural labor is discussed and a seemingly unrelated regressions (SUR) model is suggested. An application is presented analyzing three labor categories in the State of São Paulo, Brazil; farmer' s family workers, permanent ...
Francisco Alberto Pino +3 more
doaj
Om framstillinga av sørsamar i Trøndelags historie
Heimen, 2017 On the depiction of the South Saami people in Trøndelags historie The 2005 publication of a three-volume history of the Trøndelag region ignited a heated debate.
Leiv Sem
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Religions, 2020 Following the introduction of Buddhism to China, various strategies of accommodation with Chinese culture were developed, all amounting to some form of syncretism with Chinese religions, mainly Confucianism. Buddhism in pre-modern Korea displayed similar
Sem Vermeersch
doaj +1 more source
Applying SEM, Exploratory SEM, and Bayesian SEM to Personality Assessments
PsychDespite the importance of demonstrating and evaluating how structural equation modeling (SEM), exploratory structural equation modeling (ESEM), and Bayesian structural equation modeling (BSEM) work simultaneously, research comparing these analytic techniques is limited with few studies conducted to systematically compare them to each other using ...
Hyeri Hong +2 more
openaire +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source