Results 41 to 50 of about 208,948 (248)

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Comparing generative and extractive approaches to information extraction from abstracts describing randomized clinical trials

Journal of Biomedical Semantics
Background Systematic reviews of Randomized Controlled Trials (RCTs) are an important part of the evidence-based medicine paradigm. However, the creation of such systematic reviews by clinical experts is costly as well as time-consuming, and results can ...
Christian Witte, David M. Schmidt, Philipp Cimiano   +2 more
doaj   +1 more source

A Linked Open Data Service and Portal for Pre-modern Manuscript Research

Digital Humanities in the Nordic and Baltic Countries Publications, 2019
This paper presents a Linked Open Data publishing model for aggregating data from heterogeneous, distributed pre-modern manuscript databases into a global, harmonized data model and service.
Eero Hyvönen, Esko Ikkala, Jouni Tuominen, Mikko Koho, Toby Burrows, Lynn Ransom, Hanno Wijsman   +6 more
doaj   +1 more source

Adult‐Onset Subacute Sclerosing Panencephalitis Presenting With Subacute Cognitive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe the case of a 41‐year‐old man diagnosed with adult‐onset subacute sclerosing panencephalitis (SSPE). The patient presented with subacute progressive cognitive deficits and a neuropsychological profile indicating predominant frontoparietal dysfunction. MRI showed only mild parietal‐predominant cerebral atrophy.
Dennis Yeow, Nicola McKern, Vincent Oxenham, Kate Ahmad, Omar Ahmad   +4 more
wiley   +1 more source

Open challenges for the automatic synthesis of clinical trials

BMC Research Notes
Objective An important criterion for selecting clinical trials to be compared in systematic reviews and meta-analyses is that they measure the same outcomes. However, this represents a challenge as there is a wide variety of outcomes, and it is difficult
Olivia Sanchez-Graillet, David M. Schmidt, Christian Kullik, Philipp Cimiano   +3 more
doaj   +1 more source

Digital Humanities Solutions for pan-European Numismatic and Archaeological Heritage Based on Linked Open Data

Digital Humanities in the Nordic and Baltic Countries Publications, 2022
This paper discusses current challenges in archaeological cultural heritage data management and presents the interdisciplinary research project DigiNUMA.
Eljas Oksanen, Heikki Rantala, Jouni Tuominen, Michael Lewis, David Wigg-Wolf, Frida Ehrnsten, Eero Hyvönen   +6 more
doaj   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

A computational framework for modeling complex sensor network data using graph signal processing and graph neural networks in structural health monitoring

Applied Network Science, 2021
Complex networks lend themselves for the modeling of multidimensional data, such as relational and/or temporal data. In particular, when such complex data and their inherent relationships need to be formalized, complex network modeling and its resulting ...
Stefan Bloemheuvel, Jurgen van den Hoogen, Martin Atzmueller   +2 more
doaj   +1 more source

Spinal Muscular Atrophy 5q under the Mask of Myopathy: 10 Clinical Cases

Вопросы современной педиатрии, 2021
Background. Spinal muscular atrophy 5q (5q SMA) is the most frequent autosomal recessive hereditary neuromuscular disease. Molecular genetic testing is used for SMA diagnosis, and it can confirm only 5q SMA.
Sergei A. Kurbatov
doaj   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source