Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan +10 more
wiley +1 more source
Entity relationship extraction method based on dependency parsing and graph neural networks. [PDF]
Wei F +6 more
europepmc +1 more source
The Insistence of Blackness and the Persistence of Antiblackness in Ireland
ABSTRACT This paper positions Ireland as a critical site for examining the insistence of blackness and an antiblackness created and sustained through Irish ethnonationalist imaginaries and exclusionary processes. Drawing on connected sociologies and Irish Black Studies, this enquiry argues that antiblackness in Ireland operates as a generational force,
Philomena Mullen
wiley +1 more source
The association of dorsal and ventral white matter tracts with phonological and semantic processing of language in 5- to 7-year-old children. [PDF]
Mathur A +4 more
europepmc +1 more source
ABSTRACT Diagnoses of autism spectrum disorder in Australia have increased considerably in recent years. The current study investigated how the National Disability Insurance Scheme (NDIS) impacts quality of life (QoL) among carers of children with autism spectrum disorder.
Jesse Gerhard, Sharon L. Grant
wiley +1 more source
WoR<sup>+</sup> Ontology: Modeling Data and Services in Web Connected Environments. [PDF]
Kallab L, Salameh K, Chbeir R.
europepmc +1 more source
Confessions of a Poverty Researcher: My Journey Through the Foothills of Scholarship
ABSTRACT This paper describes the key events, experiences and ideas that influenced the author's career as a poverty researcher. He describes how his early disillusion with economics was replaced by a spark of interest in social issues and how his migration from the UK to Australia in the mid‐1970s provided the impetus to begin what became a lifetime ...
Peter Saunders
wiley +1 more source
The Pictorial-Semantic-Task Framework for Understanding Graph Comprehension. [PDF]
Tsai EH, Hahn Y, Siegler RS.
europepmc +1 more source
An adaptive semantic retrieval framework for digital libraries integrating graph neural networks, ontology, and user behavior. [PDF]
Bi R.
europepmc +1 more source
AI-Driven Medical Device Risk Management: A New Paradigm Integrating Large Language Models and Prompt Engineering for Standard-Risk Knowledge Graph Construction and Application. [PDF]
Zhu W +6 more
europepmc +1 more source

