Results 71 to 80 of about 2,352,460 (337)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Optimization of Hoop Layouts for Reducing Vibration Amplitude of Pipeline System Using the Semi-Analytical Model and Genetic Algorithm

IEEE Access, 2020
The pipeline system on the outside of aero-engine needs to work in resonance environment in some cases, therefore, it is necessary to reduce the vibration amplitude of pipeline systems to improve the reliability in the dynamic design stage. In this paper,
Xudong Liu, Wei Sun, Zhihui Gao
doaj   +1 more source

Analytical and semi-analytical solutions for Phi-four equation through three recent schemes

Results in Physics, 2021
This manuscript investigates the analytical and semi-analytical solutions of nonlinear phi-four (PF) equation by applying the sech–tanh expansion method, modified Ψ′Ψ-expansion method and Adomian decomposition method.
Mostafa M.A. Khater, A.A. Mousa, M.A. El-Shorbagy, Raghda A.M. Attia   +3 more
doaj   +1 more source

Hydrodynamic Modes in a Trapped Strongly Interacting Fermi Gases of Atoms

, 2005
The zero-temperature properties of a dilute two-component Fermi gas in the BCS-BEC crossover are investigated. On the basis of a generalization of the variational Schwinger method, we construct approximate semi-analytical formulae for collective ...
Alexander L Zubarev, Astrakharchik G E Combescot R Leyronas X Stringari S, Bartenstein M Altmeyer A Riedl S Jochim S Chin C Denschlag J H Grimm R, Belyaev V B, Combescot R Leyronas X, Efimov V N, Kim Y E Zubarev A L, Kim Y E Zubarev A L, Kinast J Turlapov A Thomas J E, Kinast J Turlapov A Thomas J E, Watson D K, Yeong E Kim, Zubarev A L, Zubarev A L, Zubarev A L   +14 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Semi-analytical method for solving stresses in slope under general loading conditions

Applied Rheology, 2023
Assessing the stress distribution within the slope in geotechnical engineering is critical. Despite the widely available numerical methods, no analytical solutions are available for determining the stress distribution within a slope under general loading
Wu Ping, Sun Xuejun, Zhu Dayong Zhu
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Application of Dynamic Analysis in Semi-Analytical Finite Element Method [PDF]

Materials, 2017
Analyses of dynamic responses are significantly important for the design, maintenance and rehabilitation of asphalt pavement. In order to evaluate the dynamic responses of asphalt pavement under moving loads, a specific computational program, SAFEM, was developed based on a semi-analytical finite element method.
Pengfei Liu, Qinyan Xing, Dawei Wang, Markus Oeser   +3 more
openaire   +3 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source