Results 41 to 50 of about 583,508 (260)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Prediction of Single Disc Seeding System Forces, Using a Semi-Analytical and Discrete Element Method (DEM)

open access: yesAgriculture, 2023
There is a rising interest amongst Australian farmers to use disc seeders due to their ability to operate in high residue conditions and at higher speeds, commonly in the range of 12 to 15 km h−1.
Ali Khosravani   +4 more
doaj   +1 more source

Semi-analytical solutions for the reversible Selkov model with feedback delay [PDF]

open access: yes, 2014
Semi-analytical solutions for the reversible Selkov, or glycolytic oscillations model, are considered. The model is coupled with feedback at the boundary and considered in one-dimensional reaction-diffusion cell.
Khaled Al Noufaey (20195946)   +1 more
core  

Analytical model for the propagation of small debris objects clouds after fragmentations [PDF]

open access: yes, 2015
Current debris evolutionary models usually neglect fragments smaller than 10 cm because of the high computational effort they add to the simulation. However, small-debris objects can also be dangerous to operational satellites.
Colombo, Camilla   +3 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

A Semi-analytical Model for Stellar Evolution in AGN Disks

open access: yesThe Astrophysical Journal
Disks of gas accreting onto supermassive black holes may host numerous stellar-mass objects, formed within the disk or captured from a nuclear star cluster.
Alexander J. Dittmann, Matteo Cantiello
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A Semi-Analytical Model for Gravitational Microlensing [PDF]

open access: yes, 2011
This thesis describes the theory and implementation of a semi-analytical model for gravitational microlensing. Gravitational microlensing is observed when a distant background `source' star comes into close alignment with an intermediate `lens' star. The
Chote, Paul Robin Brian   +1 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

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