Results 51 to 60 of about 67,931 (252)

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Wide sense one-dependent processes with embedded Harris chains and their applications in inventory management [PDF]

, 2003
In this paper we consider stochastic processes with an embedded Harris chain. The embedded Harris chain describes the dependence structure of the stochastic process.
Bazsa-Oldenkamp, E.M. (Emö), Iseger, P. den   +1 more
core  

First and second order semi-Markov chains for wind speed modeling

, 2012
The increasing interest in renewable energy, particularly in wind, has given rise to the necessity of accurate models for the generation of good synthetic wind speed data.
Barbu, Baviera, Collette, D’Amico, D’Amico, D’Amico, D’Amico, D’Amico, Filippo Petroni, Flavio Prattico, Gismondi, Guglielmo D’Amico, Ivanova, Janssen, Kantz, Limnios, Limnios, Nfaoui, Pasquini, Pasquini, Serva, Shamshad, Stenberg, Youcef Ettoumi, Çinlar   +24 more
core   +1 more source

Prioritizing Feasible and Impactful Actions to Enable Secure AI Development and Use in Biology

Biotechnology and Bioengineering, EarlyView.
ABSTRACT As artificial intelligence continues to enhance biological innovation, the potential for misuse must be addressed to fully unlock the potential societal benefits. While significant work has been done to evaluate general‐purpose AI and specialized biological design tools (BDTs) for biothreat creation risks, actionable steps to mitigate the risk
Josh Dettman, Emily Lathrop, Aurelia Attal‐Juncqua, Matthew Nicotra, Allison Berke   +4 more
wiley   +1 more source

Une Approche basée sur la Simulation pour l'Optimisation des Processus Décisionnels Semi-Markoviens Généralisés [PDF]

, 2008
Time is a crucial variable in planning and often requires special attention since it introduces a specific structure along with additional complexity, especially in the case of decision under uncertainty.
Fabiani, Patrick, Garcia, Frédérick, Quesnel, Gauthier, Rachelson, Emmanuel   +3 more
core  

A semi-Markov model for price returns

, 2011
We study the high frequency price dynamics of traded stocks by a model of returns using a semi-Markov approach. More precisely we assume that the intraday return are described by a discrete time homogeneous semi-Markov process and the overnight returns ...
D'Amico, Guglielmo, Petroni, Filippo
core   +1 more source

Stagewise crop yield prediction with multisource functional indices

Canadian Journal of Statistics, EarlyView.
Abstract Index insurance design involves integrating weather data, soil moisture, phenology information, and satellite imagery, which presents challenges in data fusion. This article addresses the modelling of multisource functional indices of varying lengths by constructing a stagewise ensemble of sequential models.
Jing Zou, Ostap Okhrin
wiley   +1 more source

Reweighting Scheme for the Calculation of Grand‐Canonical Expectation Values in Quantum Monte Carlo Simulations With a Fermion Sign Problem

Contributions to Plasma Physics, EarlyView.
ABSTRACT Ab initio path integral Monte Carlo (PIMC) simulations constitute the gold standard for the estimation of a broad range of equilibrium properties of a host of interacting quantum many‐body systems spanning a broad range of conditions from ultracold atoms to warm dense quantum plasmas.
Paul Hamann, Jan Vorberger, Tobias Dornheim   +2 more
wiley   +1 more source

Habitat complexity and prey composition shape an apex predator's habitat use across contrasting landscapes

Ecography, EarlyView.
The spatial ecology of stalk‐and‐ambush predators like the Eurasian lynx Lynx lynx depends on prey availability and environmental features, yet the relative roles of these factors remain unclear at large spatial scales. In this study, we analysed lynx habitat use across central and southern Finland using snow‐track data from the Wildlife Triangle ...
Francesca Malcangi, Caio Graco‐Roza, Andreas Lindén, Janne Sundell, John Loehr   +4 more
wiley   +1 more source

A Semi-Markov Modulated Interest Rate Model

, 2012
In this paper we propose a semi-Markov modulated model of interest rates. We assume that the switching process is a semi-Markov process with finite state space E and the modulated process is a diffusive process.
D'Amico, Guglielmo, Manca, Raimondo, Salvi, Giovanni   +2 more
core   +1 more source