Results 41 to 50 of about 1,866 (249)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Proper Semi-Slant Pseudo-Riemannian Submersions in Para-Kaehler Geometry

International Electronic Journal of Geometry, 2022
In this paper, we examine the proper semi-slant pseudo-Riemannian submersions in para-Kaehler geometry and prove some fundamental results on such submersions. In particular we obtain curvature relations in para-Kaehler space forms. Moreover, we provide examples of proper semi-slant pseudo-Riemannian submersions.
Esra Başarır Noyan, Yılmaz Gündüzalp   +1 more
openaire   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Trivial Homology Groups of Warped Product Semi-Slant Submanifolds in Kenmotsu Space Forms

Axioms
This paper investigates the relationship between homology groups and warped product semi-slant submanifolds in Kenmotsu space forms. Some rigidity theorems for vanishing homology groups on warped product semi-slant submanifolds are obtained using the ...
Noura M. Alhouiti, Ali H. Alkhaldi, Akram Ali, Fatemah Mofarreh, Piscoran Laurian-Ioan   +4 more
doaj   +1 more source

Estimation of inequalities for warped product semi-slant submanifolds of Kenmotsu space forms

Journal of Inequalities and Applications, 2016
In this paper, we construct the geometric inequalities for the squared norm of the mean curvature and warping functions of warped product semi-slant submanifolds in Kenmotsu space forms. The equality cases are also discussed.
Misbah Liaqat, Piscoran Laurian-Ioan, Wan Ainun Mior Othman, Akram Ali, Abdullah Gani, Cenap Ozel   +5 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Gradient Expanding Ricci Solitons Type Inequalities on Submanifolds in Quaternion Kaehler Manifolds with Bi-Slant Factor

Mathematics
In this article, we study the Ricci soliton on quaternion bi-slant submanifolds of quaternion Kaehler manifolds. We obtain a lower-bound-type inequality in terms of expanding gradient Ricci solitons with a gradient-type vector field for the quaternion bi-
Ali H. Hakami, Mohd Danish Siddiqi
doaj   +1 more source