Results 51 to 60 of about 2,153 (264)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Proper Semi-Slant Pseudo-Riemannian Submersions in Para-Kaehler Geometry

International Electronic Journal of Geometry, 2022
In this paper, we examine the proper semi-slant pseudo-Riemannian submersions in para-Kaehler geometry and prove some fundamental results on such submersions. In particular we obtain curvature relations in para-Kaehler space forms. Moreover, we provide examples of proper semi-slant pseudo-Riemannian submersions.
Esra Başarır Noyan, Yılmaz Gündüzalp   +1 more
openaire   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Trivial Homology Groups of Warped Product Semi-Slant Submanifolds in Kenmotsu Space Forms

Axioms
This paper investigates the relationship between homology groups and warped product semi-slant submanifolds in Kenmotsu space forms. Some rigidity theorems for vanishing homology groups on warped product semi-slant submanifolds are obtained using the ...
Noura M. Alhouiti, Ali H. Alkhaldi, Akram Ali, Fatemah Mofarreh, Piscoran Laurian-Ioan   +4 more
doaj   +1 more source

Estimation of inequalities for warped product semi-slant submanifolds of Kenmotsu space forms

Journal of Inequalities and Applications, 2016
In this paper, we construct the geometric inequalities for the squared norm of the mean curvature and warping functions of warped product semi-slant submanifolds in Kenmotsu space forms. The equality cases are also discussed.
Misbah Liaqat, Piscoran Laurian-Ioan, Wan Ainun Mior Othman, Akram Ali, Abdullah Gani, Cenap Ozel   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Gradient Expanding Ricci Solitons Type Inequalities on Submanifolds in Quaternion Kaehler Manifolds with Bi-Slant Factor

Mathematics
In this article, we study the Ricci soliton on quaternion bi-slant submanifolds of quaternion Kaehler manifolds. We obtain a lower-bound-type inequality in terms of expanding gradient Ricci solitons with a gradient-type vector field for the quaternion bi-
Ali H. Hakami, Mohd Danish Siddiqi
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

On the coupled unsaturated–saturated flow process induced by vertical, horizontal, and slant wells in unconfined aquifers [PDF]

Hydrology and Earth System Sciences, 2017
Conventional models of pumping tests in unconfined aquifers often neglect the unsaturated flow process. This study concerns the coupled unsaturated–saturated flow process induced by vertical, horizontal, and slant wells positioned in an unconfined ...
X. Liang, H. Zhan, Y.-K. Zhang, J. Liu
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source