Results 31 to 40 of about 1,477,294 (253)

Seminal plasma metabolome in relation to semen quality and urinary phthalate metabolites among Chinese adult men

Environment International, 2019
Background: A growing body of evidence has found links between endocrine disruptor phthalates and male reproductive disorders, but the mechanisms underlying these relationships are poorly known.
Yi-Xin Wang, Yan Wu, Heng-Gui Chen, Peng Duan, Liang Wang, He-Qing Shen, Wen-Qing Lu, Bin Sun, Qi Wang, Bo Zhang, Jorge E. Chavarro, Jie Zhang, An Pan   +12 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The effects of urethritis on seminal plasma HIV-1 RNA loads in homosexual men not receiving antiretroviral therapy [PDF]

, 2005
Objectives: To examine the effects of urethritis and its treatment on semen plasma HIV-1 RNA load in HIV-1 infected men not receiving antiretroviral therapy (ART), in a developed world setting. Methods: Prospective case-control study.
Kirk, S., Copas, A.J., Kaye, S., Pillay, D., Sadiq, S.T., Weller, I.V.D., Taylor, S., Bennett, J., Drake, S.M.   +8 more
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Biochemical changes of cryopreserved seminal plasma and spermatozoa of the giant grouper Epinephelus lanceolatus after preservation and transportation using dry-ice

Egyptian Journal of Aquatic Research, 2020
The present study aims to investigate the effects of exposure of the seminal plasma and spermatozoa of the giant grouper Epinephelus lanceolatus to dry ice (−79 °C) during transport on their quality. In all, 15 amino acid compounds were determined.
Che Ismail Che-Zulkifli, Koh Ivan Chong Chu, Shahreza Md Sheriff, Hairul Hafiz Mahsol, Md Ali Amatul-Samahah, Mohamad Nor Azra, Mhd Ikhwanuddin   +6 more
doaj   +1 more source

Seminal Plasma Proteins as Potential Markers of Semen Characteristics in Buffalo and Bovine Bulls [PDF]

Journal of Animal and Poultry Production, 2016
This study aimed to find a link between seminal plasma protein profile and semen characteristics, freezing ability and subsequent field fertility of bovine and buffalo bulls.
E. El-Siefy, A. Ashour, F. El-Keraby, A. Kadoom   +3 more
doaj   +1 more source