Results 41 to 50 of about 1,477,294 (253)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Inhibition of Plasma Kallikrein with Aprotinin in porcine endotoxin Shock [PDF]

, 1993
Activation of the contact phase of coagulation has been implicated in the pathogenesis of septic shock. We wanted to determine if inhibition of plasma kallikrein can prevent arterial hypotension and liberation of kinins from kininogen, induced by an ...
Siebeck, Matthias, Shimamoto, Kazuaki, Weipert, Joachim, Kroworsch, Peter, Spannagl, Michael, Schweiberer, Leonhard, Jochum, Marianne, Fritz, Hans, Fink, Edwin   +8 more
core   +1 more source

Seminal plasma enables selection and monitoring of active surveillance candidates using nuclear magnetic resonance-based metabolomics: A preliminary investigation [PDF]

, 2017
Background: Diagnosis and monitoring of localized prostate cancer requires discovery and validation of noninvasive biomarkers. Nuclear magnetic resonance (NMR)-based metabolomics of seminal plasma reportedly improves diagnostic accuracy, but requires ...
Martin F. Lavin, Schirra, Horst Joachim, Chow, Clement W.K., Gardiner, Robert A, Lavin, Martin F., Roberts, Matthew J, Chow, Clement WK, Renee S. Richards, Clement W.K. Chow, Marion Buck, Horst Joachim Schirra, Matthew J. Roberts, Robert A. Gardiner, Lavin, Martin F, John Yaxley, Yaxley, John, Roberts, Matthew J., Buck, Marion, Richards, Renee S, Richards, Renee S., Gardiner, Robert A.   +20 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Human Seminal Plasma Proteome Study: a Search for Male Infertility Biomarkers

Balkan Journal of Medical Genetics, 2012
Seminal plasma is a potential source of biomarkers for many disorders of the male reproductive system including male infertility. Knowledge of the peptide and protein components of seminal fluid is accumulating especially with the appearance of ...
Davalieva Katarina, Kiprijanovska S, Noveski P, Plaseska-Karanfilska D, Plaseski T, Kocevska B   +5 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Perfil proteico e análise da atividade enzimática no plasma seminal de catetos (pecari tajacu linnaeus, 1758) [PDF]

, 2013
The main mechanisms involved in fertility of male include post-translational modifications as well as the presence or absence of certain proteins in seminal plasma.
Santos, Erika Aparecida Araújo dos
core  

Seminal-Plasma-Mediated Effects on Sperm Performance in Humans

, 2022
Seminal plasma (SP) plays a crucial role in reproduction and contains a large number of proteins, many of which may potentially modify sperm functionality.
Turunen, Tanja, Tanja Turunen, Jukka Kekäläinen, Kekäläinen, Jukka, Martina Magris, Magris, Martina, Malinen, Marjo, Marjo Malinen   +7 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source