Results 71 to 80 of about 110,687 (287)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Large Differences in Small RNA Composition Between Human Biofluids. [PDF]

, 2018
Extracellular microRNAs (miRNAs) and other small RNAs are implicated in cellular communication and may be useful as disease biomarkers. We systematically compared small RNAs in 12 human biofluid types using RNA sequencing (RNA-seq).
Barczak, Andrea J, Bhakta, Nirav R, Cakmak, Hakan, Erle, David J, Fisher, Susan, Godoy, Paula M, MacKenzie, Tippi C, Patel, Tushar, Price, Richard W, Smith, James F, Woodruff, Prescott G   +10 more
core  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Avaliação espermática e da concentração de proteínas solúveis no plasma seminal de bodes da raça Alpina em regime de monta controlada Reproductive performance, soluble proteins of the seminal plasm and hypoosmotic test in male goats of the Alpine breed under controlled mating

Revista Brasileira de Zootecnia, 2006
Foram estudadas as relações entre a concentração de proteínas solúveis do plasma seminal, o teste hipoosmótico, a análise física e morfológica do sêmen e o desempenho reprodutivo de bodes da raça Alpina em regime de monta controlada.
Leonardo Franco Martins, Maria Cristina Baracat Pereira, José Domingos Guimarães, Eduardo Paulino da Costa, Thiago da Silva Silveira, Ciro Alexandre Alves Torres, Marcelo Teixeira Rodrigues, Vandberg Barbosa Braz   +7 more
doaj   +1 more source

Isolation and characterization of gelatin-binding proteins from goat seminal plasma [PDF]

, 2003
A family of proteins designated BSP-A1, BSP-A2, BSP-A3 and BSP-30 kDa (collectively called BSP proteins for Bovine Seminal Plasma proteins) constitute the major protein fraction in the bull seminal plasma.
Lazure Claude, Manjunath Puttaswamy, Villemure Michèle   +2 more
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Actividad de la Glutatión Peroxidasa y la Superóxido Dismutasa en sangre y plasma seminal en caballos colombianos Atividade das enzimas antioxidantes: glutationa peroxidase e superóxido dismutase no sangue e plasma em cavalos colombiano Glutathione Peroxidase and Superoxide Dismutase activities in blood and seminal plasma in colombian stallions

Revista Colombiana de Ciencias Pecuarias, 2012
Objetivo: determinar la actividad de las enzimas antioxidantes Glutatión Peroxidasa (GSH-Px; EC 1.11.1.9) y Superóxido Dismutasa (SOD; EC 1.15.1.1) en sangre y plasma seminal de 25 caballos reproductores criollos colombianos, clínicamente sanos ...
Néstor A Villa, Daniel Castaño, Paulo C Duque, Alejandro Ceballos   +3 more
doaj  

Evaluation the Effect of Interleukin-6 and Tumor Necrosis Factor in Semen Quality of Infertile Men with Varicocele.

Kufa Journal for Nursing Sciences, 2016
Objective: The study was designed to evaluation of effect Interleukin-6 and Tumor necrosis factor in seminal plasma to semen quality in infertile men with varicocele.
Salman A. Al-Jibouri, Raeed T. Al-karrawe, Dhafer Taher Al-Wades   +2 more
doaj   +1 more source

Seminal fluid and cytokine control of regulatory T-cells in murine pregnancy. [PDF]

, 2010
For successful pregnancy, the maternal immune system must tolerate the presence of a fetus that expresses alloantigens. The appropriate and timely acquisition of this state of tolerance is critical and emerging evidence suggests that it needs to be ...
Guerin, Leigh R.
core   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source