Results 191 to 200 of about 731,505 (299)

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Sens uprawiania nauki, sens publikowania, sens regulacji

Sylwan, 1983
openaire   +1 more source

Congenital Microgastria With Esophageal Stricture: An Extremely Rare Foregut Anomaly Necessitating Early Surgical Intervention. [PDF]

ACG Case Rep J
Gupta A, Aravind A, Srivastava A, Mandelia A, Sen Sarma M.   +4 more
europepmc   +1 more source

Checkpoint‐Directed Glycoengineering Reprograms the Vascular Lumen for Siglec‐Mediated Immune Regulation

Advanced Science, EarlyView.
Checkpoint‐directed glycoengineering installs sialylated ligands on the donor vascular lumen during ex vivo preservation, creating a localized Siglec‐7/9‐engaging interface. The engineered glycocalyx suppresses immune‐cell activation, complement deposition, and microvascular injury in arterial and kidney allografts while preserving endothelial ...
Md Mohosin Rana, Javairia F. Rahim, Aaron P. Bernstein, Peyman Malek Mohammadi Nouri, Lyann Sim, Winnie Enns, Jenice M. Dumlao, Haiming D. Luo, Irina Chafeeva, Hong‐Ming Chen, Aizhou Wang, Jiao‐Jing Wang, Edward N. Schmidt, Zheng Jenny Zhang, Marcelo Cypel, Christopher Nguan, Matthew S. Macauley, Stephen G. Withers, Jonathan C. Choy, Jayachandran N. Kizhakkedathu   +19 more
wiley   +1 more source

Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer. [PDF]

Science
Hinterleitner C, Barthet VJA, Goldberg HV, Vogt KC, Perea AM, Hillger LR, Ruiz S, McHugh D, Ho YJ, Chaves-Perez A, Skamagki M, Flowers S, Styers HC, Rekhtman N, Zhuang X, Dessotti Barretto G, Li X, Watson JT, Luan W, Simon J, Tammela T, Gardner R, Rudin CM, Romesser PB, Bott MJ, Filliol A, Heller DA, Lowe SW.   +27 more
europepmc   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Stimpsonia danxiacola (Primulaceae), a new species endemic to danxia landscape from southern China. [PDF]

PhytoKeys
Zhao XL, Huang YS, Liao LJ, Peng LF, Fan Q.   +4 more
europepmc   +1 more source

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

Correction for Sen et al., "Distinct motors, shared mechanics: unifying principles of microbial gliding". [PDF]

J Bacteriol
Sen S, Henderson EC, Garcia-Pichel F, Kaplan M, Shrivastava A.   +4 more
europepmc   +1 more source