Results 211 to 220 of about 731,505 (299)

Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation

Advanced Science, EarlyView.
Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He   +10 more
wiley   +1 more source

A Fish MDA5 Integrates Canonical RIG‐I and MDA5 Ligand Recognition

Advanced Science, EarlyView.
These results show that the large yellow croaker lacks RIG‐I, yet its MDA5 senses both 5′ppp‐dsRNA and long dsRNA. A flexible RNA‐capping loop in the MDA5 C‐terminal domain enables two ligand‐binding modes. This dual recognition signals through MAVS–STING–TBK1/IRF3 and induces type I interferons, revealing unexpected plasticity in vertebrate antiviral ...
Wenxing Li, Yuan Feng, Huazhi Chen, Jiamei Liu, Álvaro Fernández Montero, Jiangtao Gao, Jingqun Ao, Xinhua Chen   +7 more
wiley   +1 more source

Sacral Neural Crest‐Derived Extracellular Vesicles Promote Pelvic Ganglion Repair Through Anti‐Pyroptotic Effects Involving ANXA1–FPR2 Signaling

Advanced Science, EarlyView.
Extracellular vesicles derived from human pluripotent stem cell‐derived sacral neural crest cells promote repair of injured major pelvic ganglia and improve colorectal function. These vesicles reduce oxidative stress and pyroptosis, with ANXA1–FPR2 signaling contributing to their protective effects, and show a favorable therapeutic profile compared ...
Ting Yang, Wenwei Liu, Hufei Wang, Yuxin Wu, Yuanchen Ma, Xiaofeng Wang, Tianxiang Lei, Qiao Tang, Yebohao Zhou, Weiqiang Li, Andy Peng Xiang, Wu Song   +11 more
wiley   +1 more source

Retraction Note: Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models. [PDF]

J Neuroinflammation
Iba M, Kim C, Sallin M, Kwon S, Verma A, Overk C, Rissman RA, Sen R, Sen JM, Masliah E.   +9 more
europepmc   +1 more source

Multidimensionally Programming Photoswitching via Orthogonal Covalent‐Noncovalent Chemistry for Dual‐Track Time‐Resolved Optical Encryption

Advanced Science, EarlyView.
A dual‐track time‐resolved encryption strategy with independent information display during photo‐bleaching and thermal‐recovery stages has been realized through multiple temporal encoding units derived from orthogonal covalent‐noncovalent programming of donor–acceptor Stenhouse adduct photoswitching.
Qi Guo, Lewei Li, Meihui Yan, Yuzhao Yang, Dengchong Feng, Shaolin Lu, Cheng Wang, Min Cao, Haiqiang Wu, Zhongke Yuan, Dingshan Yu, Xudong Chen   +11 more
wiley   +1 more source

Innovative niosome screening for efficient gene delivery in senescent primary umbilical cord stroma-derived MSCs. [PDF]

Drug Deliv
Iglesias-Fente A, López-Seijas J, Arufe MC, Fafián-Labora JA, Rey-Rico A.   +4 more
europepmc   +1 more source

To Be or Not to Be Eutectic: Anomalous Glass Forming Ability Governed by Melt Structural Complexity

Advanced Science, EarlyView.
Challenging the eutectic rule, congruently melting Ti–Cu alloys show greater glass‐forming ability than their eutectic counterparts. This arises from the congruent melt's structural complexity: higher cluster diversity and stronger inter‐cluster correlations from entropy–enthalpy competition.
Wei Chen, Xuerui Wei, Chengzhe Wang, Zhichao Lu, Fan Zhang, Yan Huang, Yibo Zhang, Liang Wang, Saichao Cao, Chunyin Zhou, Ke Yang, Zhendong Fu, Jinkui Zhao, Dongbai Sun, Fanqiang Meng, Zhou Zhou, Xun‐li Wang, Weihua Wang, Dong Ma   +18 more
wiley   +1 more source

Integrated Spatial and Bulk Transcriptomic Analysis Identifies a Multicellular Ecosystem Involved in Progression of Young Breast Cancer. [PDF]

Cancer Med
Chen X, Liang Z, Chen X, Ouyang Q, Chen Q, Zhu L, Li S, Chen K.   +7 more
europepmc   +1 more source

Hepatocyte CBX2 Safeguards Hepatic Lipid Homeostasis by Elevating Ca2+‐CaMKK2‐AMPK Signaling to Counter MASLD

Advanced Science, EarlyView.
In hepatocytes, CBX2 promotes H3K4me3 enrichment at the Orai1 promoter to enhance Orai1 transcriptional activation, thereby increasing intracellular Ca2+ levels. The elevated Ca2+ activates the CaMKK2‐AMPK signaling cascade, resulting in ACC phosphorylation and downstream metabolic regulation. This cascade suppresses de novo lipogenesis (Fasn, Acc, Scd‐
Xiang Wei, Li Lin, Xiuyun Wang, Hui Du, Menglong Zhang, Kechao Tang, Han Gao, Xinrui Xie, Jingya Gao, Xu Wang, Zhenglin Wang, Siwei Huang, Lei Zhang, Fang Gu, Gong‐Hong Wei, Yinliang Qi, Wei Chen, Yongsheng Chang, Huabing Zhang   +18 more
wiley   +1 more source

Deep learning-based detection and classification of airway nodules on CT for early medical intervention. [PDF]

Insights Imaging
Liu S, Yi P, Fan Y, Hu J, Zheng C, Lei P, Li S, Yang F, Li C, Hou Y, Li Y, Luo G, Fang X, Zheng H, Bai H, Zhou H, Liao W.   +16 more
europepmc   +1 more source