Results 1 to 10 of about 1,044 (100)

Seneca Valley Virus Degrades STING via PERK and ATF6-Mediated Reticulophagy. [PDF]

Viruses, 2023
Seneca Valley Virus (SVV), a member of the Picornaviridae family, is an emerging porcine virus that can cause vesicular disease in pigs. However, the immune evasion mechanism of SVV remains unclear, as does its interaction with other pathways. STING (Stimulator of interferon genes) is typically recognized as a critical factor in innate immune responses
Bai L, Zhang R, Zheng H, Zhang Z, Zhang Z, Li Y.   +5 more
europepmc   +5 more sources

CRISPR-Cas13d Exhibits Robust Antiviral Activity Against Seneca Valley Virus. [PDF]

Front Microbiol, 2022
In recent years, Seneca Valley virus (SVV) as a newly identified pathogen of porcine vesicular disease spread quickly and has posed a potential threat to the swine industry in several countries resulting in economic losses. Considering the evolution of SVV, attention should be given to controlling SVV epidemics.
Zhang YY, Sun MX, Lian Y, Wang TY, Jia MY, Leng C, Chen M, Bai YZ, Meng F, Cai XH, Tang YD.   +10 more
europepmc   +6 more sources

Intercellular transmission of Seneca Valley virus mediated by exosomes. [PDF]

Vet Res, 2020
AbstractSeneca Valley virus (SVV) is a non-encapsulated single-stranded positive-strand RNA virus whose transmission routes have not yet been fully elucidated. Exosomes have been implicated in the intercellular transport of a variety of materials, such as proteins, RNA, and liposomes. However, whether exosomes can mediate SVV intercellular transmission
Xu G, Xu S, Shi X, Shen C, Hao J, Yan M, Zhang D, Zhu Z, Zhang K, Zheng H, Liu X.   +10 more
europepmc   +9 more sources

Seneca Valley virus 3C^pro antagonizes host innate immune responses and programmed cell death. [PDF]

Front Microbiol, 2023
Seneca Valley virus (SVV), a member of the Picornaviridae family, may cause serious water blister diseases in pregnant sows and acute death in newborn piglets, which have resulted in economic losses in pig production. The 3C protease is a vital enzyme for SVV maturation and is capable of regulating protein cleavage and RNA replication of the virus ...
Zhang XY, Li YY, Huang HX, Zhao CC, Lei XX, Zhao BP, Lu JY, Lan T, Sun WC.   +8 more
europepmc   +5 more sources

Seneca Valley Virus 3C^pro Cleaves PABPC1 to Promote Viral Replication. [PDF]

Pathogens, 2020
Seneca Valley Virus (SVV) is an oncolytic virus of the Picornaviridae family, which has emerged in recent years. The impact of SVV on host cell translation remains unknown. Here, we showed, for the first time, that SVV infection cleaved poly(A) binding protein cytoplasmic 1 (PABPC1).
Xue Q, Liu H, Zhu Z, Xue Z, Liu X, Zheng H.   +5 more
europepmc   +6 more sources

Correction to: Intercellular transmission of Seneca Valley virus mediated by exosomes. [PDF]

Vet Res, 2020
An amendment to this paper has been published and can be accessed via the original article.
Xu G, Xu S, Shi X, Shen C, Hao J, Yan M, Zhang D, Zhu Z, Zhang K, Zheng H, Liu X.   +10 more
europepmc   +6 more sources

Seneca Valley virus infection exploits DNA damage response to facilitate viral replication. [PDF]

J Virol
ABSTRACT Seneca Valley virus (SVV) is an emerging pathogen that causes severe vesicular diseases in swine, posing a significant threat to the global pork industry. DNA and RNA viruses manipulate the host DNA damage response (DDR) to modulate cellular machinery and facilitate their life cycles.
Song J, Li Z, Yang J, Ma R, Wang D, Quan R, Wen X, Liu J.   +7 more
europepmc   +5 more sources

In vitro and in vivo antiviral activity of monolaurin against Seneca Valley virus. [PDF]

Front Vet Sci, 2023
IntroductionSurveillance of the Seneca Valley virus (SVV) shows a disproportionately higher incidence on Chinese pig farms. Currently, there are no vaccines or drugs to treat SVV infection effectively and effective treatment options are urgently needed.MethodsIn this study, we evaluated the antiviral activity of the following medium-chain fatty acids ...
Su B, Wang Y, Jian S, Tang H, Deng H, Zhu L, Zhao X, Liu J, Cheng H, Zhang L, Hu Y, Xu Z.   +11 more
europepmc   +5 more sources

Seneca Valley Virus 3C ^pro Cleaves Heterogeneous Nuclear Ribonucleoprotein K to Facilitate Viral Replication. [PDF]

Front Microbiol, 2022
Seneca Valley virus (SVV) has emerged as an important pathogen that is associated with idiopathic vesicular infection in pigs, causing a potential threat to the global swine industry. The heterogeneous nuclear ribonucleoprotein K (hnRNP K) that shuttles between the nucleus and cytoplasm plays an important role in viral infection.
Song J, Quan R, Wang D, Liu J.
europepmc   +5 more sources

The Seneca Valley virus 3C protease cleaves DCP1A to attenuate its antiviral effects. [PDF]

Vet Res
Abstract Seneca Valley virus (SVV), a new member of Picornaviridae, causes idiopathic vesicular symptoms in pregnant sows and acute death in neonatal piglets, considerably damaging the swine industry. The viral protease 3C (3Cpro) cleaves host immune-related molecules to create a favorable environment for viral replication.
Yang J, Li Z, Ma R, Xie S, Wang D, Quan R, Wen X, Song J.   +7 more
europepmc   +4 more sources