Results 11 to 20 of about 4,708 (179)

Seneca Valley Virus Induces DHX30 Cleavage to Antagonize Its Antiviral Effects. [PDF]

J Virol, 2022
DHX30, an RNA helicase, is identified as a 3C pro -interacting protein regulating Seneca Valley virus (SVV) replication dependent on its helicase activity. DHX30 functioned as a viral-RNA binding protein that inhibited SVV replication at the early stage of virus infection.
Wen W, Zheng Z, Wang H, Zhao Q, Yin M, Chen H, Li X, Qian P.   +7 more
europepmc   +5 more sources

Seneca Valley virus 3C protease cleaves HDAC4 to antagonize type I interferon signaling. [PDF]

J Virol
ABSTRACT Seneca Valley virus (SVV) is a newly identified pathogen that poses a notable threat to the global pig industry. SVV has evolved multiple strategies to evade host antiviral innate immune responses. However, the underlying molecular mechanisms have not yet been fully elucidated.
Li Z, Yang J, Ma R, Xie S, Wang D, Quan R, Wen X, Liu J, Song J.   +8 more
europepmc   +5 more sources

Seneca Valley virus 3C^pro degrades heterogeneous nuclear ribonucleoprotein A1 to facilitate viral replication. [PDF]

Virulence, 2021
Seneca Valley virus (SVV) is a recently-identified important pathogen that is closely related to idiopathic vesicular disease in swine. Infection of SVV has been shown to induce a variety of cellular factors and their activations are essential for viral replication, but whether heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) involved in SVV ...
Song J, Wang D, Quan R, Liu J.
europepmc   +5 more sources

Seneca Valley Virus 3C^pro Mediates Cleavage and Redistribution of Nucleolin To Facilitate Viral Replication. [PDF]

Microbiol Spectr, 2022
The nucleolus is a subnuclear cellular compartment, and nucleolin (NCL) resides predominantly in the nucleolus. NCL participates in viral replication, translation, internalization, and also serves as a receptor for virus entry.
Song J, Quan R, Wang D, Liu J.
europepmc   +5 more sources

Real-time detection of Seneca Valley virus by one-tube RPA-CRISPR/Cas12a assay. [PDF]

Front Cell Infect Microbiol, 2023
IntroductionSenecavirus A (SVA) is a highly contagious virus that causes vesicular disease in pigs. At present, laboratory detection methods, such as virus isolation and polymerase chain reaction (PCR), required precision instruments and qualified ...
Ma L, Zhu M, Meng Q, Wang Y, Wang X.
europepmc   +2 more sources

Rapid detection of Seneca Valley virus based on reverse transcription recombinase polymerase amplification and CRISPR-Cas13a. [PDF]

Virulence
The Seneca Valley virus (SVV) is an emerging novel etiological agent that triggers vesicular stomatitis in pigs. SVV leads to considerable financial detriment to the global swine industry.
Wu Y, Su J, Sun J, Li Z, Yang J, Wu C, Liu Z, Wang J, Wang Y, Liu J, Duan L, Wang C, Zhu G, Wen X.   +13 more
europepmc   +2 more sources

Review of Seneca Valley Virus: A Call for Increased Surveillance and Research [PDF]

Frontiers in Microbiology, 2018
El virus del Valle de Séneca (SVV) ha causado recientemente muchas enfermedades vesiculares en cerdos en diferentes regiones y países. Como nuevo agente causante de la enfermedad vesicular porcina, la SVV ha evolucionado y se ha propagado rápidamente.
Xiangle Zhang, Zixiang Zhu, Fan Yang, Weijun Cao, Hong Tian, Keshan Zhang, Dan Li, Xiangtao Liu   +7 more
openaire   +4 more sources

Seneca Valley virus replicons are packaged in trans and have the capacity to overcome the limitations of viral transgene expression. [PDF]

Mol Ther Oncolytics, 2023
Oncolytic viruses (OVs) promote the anti-tumor immune response as their replication, and the subsequent lysis of tumor cells, triggers the activation of immune-sensing pathways.
Bryant JD, Lee JS, De Almeida A, Jacques J, Chang CH, Fassler W, Quéva C, Lerner L, Kennedy EM.   +8 more
europepmc   +2 more sources

Cryo-EM structure of the Seneca Valley virus A-particle and related structural states. [PDF]

J Virol
Picornavirus cell entry requires a series of capsid protein conformational changes leading to genome uncoating. For enteroviruses, receptor binding triggers the transition from a full (F) capsid to an altered (A) particle before releasing its genome and ...
Kumaran R, Jayawardena N, Chen K-L, Eruera A-R, Hodgkinson-Bean J, Burga LN, Wolf M, Bostina M.   +7 more
europepmc   +2 more sources

Evolving role of seneca valley virus and its biomarker TEM8/ANTXR1 in cancer therapeutics. [PDF]

Front Mol Biosci, 2022
Oncolytic viruses have made a significant inroad in cancer drug development. Numerous clinical trials are currently investigating oncolytic viruses both as single agents or in combination with various immunomodulators.
Corbett V, Hallenbeck P, Rychahou P, Chauhan A.   +3 more
europepmc   +2 more sources