Results 21 to 30 of about 4,708 (179)

Pathogenicity of Seneca Valley virus in pigs and detection in Culicoides from an infected pig farm. [PDF]

Virol J, 2021
Background Porcine vesicular disease is caused by the Seneca Valley virus (SVV), it is a novel Picornaviridae, which is prevalent in several countries.
Zhang J, Li C, Meng Y, Xie Y, Shi N, Zhang H, Yu C, Nan F, Xie C, Ha Z, Han J, Li Z, Li Q, Wang P, Gao X, Jin N, Lu H.   +16 more
europepmc   +2 more sources

Seneca Valley Virus Exploits TEM8, a Collagen Receptor Implicated in Tumor Growth [PDF]

Frontiers in Oncology, 2018
Recent studies reveal that Seneca Valley Virus (SVV) exploits tumor endothelial marker 8 (TEM8) for cellular entry, the same surface receptor pirated by bacterial-derived anthrax toxin. This observation is particularly significant as SVV is a known oncolytic virus which selectively infects and kills tumor cells, particularly those of neuroendocrine ...
Evans, David J., Wasinger, Alexa M., Brey, Robert N., Dunleavey, James M., St Croix, Brad, Bann, James G.   +5 more
openaire   +5 more sources

Synergetic contributions of Seneca Valley virus 3 C and 3D proteins to induction of ferroptosis for viral replication. [PDF]

Cell Mol Life Sci
Seneca Valley virus (SVV) infection leads to severe vesicular diseases in pigs, posing a significant threat to the global swine industry. Ferroptosis, a novel form of non-apoptotic cell death, is characterized by iron-dependent phospholipid peroxidation.
Song J, Yang J, Ma R, Li Z, Su J, Xie S, Cheng P.   +6 more
europepmc   +2 more sources

Seneca valley virus VP4 protein regulates the transcription of different cytokines <i>in vitro</i>. [PDF]

Front Vet Sci
To understand the effect of Seneca valley virus (SVV) VP4 protein on innate immune factors, the VP4 gene was cloned into the pEGFP-C1 expression plasmid to construct the pEGFP-C1-VP4 recombinant plasmid. After the recombinant plasmid was transfected into
Leng C, Ge Y, Ruan M, Zhao W, Yang X, Gao S, Zhai H, Li D, Rao D, Dong J.   +9 more
europepmc   +2 more sources

Seneca Valley virus circumvents Gasdermin A-mediated inflammation by targeting the pore-formation domain for cleavage. [PDF]

mBio
Members of the gasdermin (GSDM) family are critical for inducing programmable pyroptosis by forming pores on the cell membrane. GSDMB, GSDMC, GSDMD, and GSDME are activated by caspases or granzyme, leading to the release of their autoinhibitory domains ...
Yin H, Zhao Z, Yan Y, Yuan Y, Qu W, Wang H, Zhu C, Li P, Li X.   +8 more
europepmc   +2 more sources

Seneca Valley Virus 2C and 3Cpro Induce Apoptosis via Mitochondrion-Mediated Intrinsic Pathway [PDF]

Frontiers in Microbiology, 2019
Seneca Valley virus (SVV) is the only member of the genus Senecavirus of the Picornaviridae family. SVV can selectively infect and lyse tumor cells with neuroendocrine features and is used as an oncolytic virus for treating small-cell lung cancers. However, the detailed mechanism underlying SVV-mediated destruction of tumor cells remains unclear.
Tingting Liu, Tingting Liu, Xiangmin Li, Xiangmin Li, Xiangmin Li, Xiangmin Li, Mengge Wu, Mengge Wu, Liuxing Qin, Liuxing Qin, Huanchun Chen, Huanchun Chen, Huanchun Chen, Huanchun Chen, Ping Qian, Ping Qian, Ping Qian, Ping Qian   +17 more
openaire   +4 more sources

Seneca Valley virus induces mitochondrial apoptosis by activating ER stress or the PERK pathway based on Ca²⁺ transfer from ER to mitochondria. [PDF]

J Virol
Seneca Valley virus (SVV), also known as Senecavirus A, a porcine pathogen that causes vesicular diseases, is prevalent in pig herds worldwide. SVV infection induces endoplasmic reticulum (ER) stress in PK-15 and BHK-21 cells, accompanied by activation ...
Hou L, Yang X, Liu C, Yu J, Wu Z, Wang Y, Zeng P, Guo J, Shi Y, Zhou J, Liu J.   +10 more
europepmc   +2 more sources

Genome-Wide Analysis of Long Noncoding RNA Profiles in Seneca Valley Virus-Infected PK15 Cells. [PDF]

Front Vet Sci, 2022
Long noncoding RNAs (lncRNAs) have been demonstrated to play key roles in various biological processes. However, the contributions of lncRNAs to Seneca Valley virus (SVV) infection and host defense remain largely unknown.
Dong J, Rao D, Chen M, Zhao P, Huang L.
europepmc   +2 more sources

Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance Anthrax toxin receptor 1 (ANTXR1), also known as Tumor Endothelial Marker 8, is overexpressed on the surface of tumor cells in over 60% of human cancers. A serious drawback for developing specific ligands for targeted therapy against ANTXR1 is the cross-reactivity with ANTXR2.
Nadishka Jayawardena, Laura N. Burga, Richard A. Easingwood, Yoshimasa Takizawa, Matthias Wolf, Mihnea Bostina   +5 more
openaire   +4 more sources

Dexamethasone treatment did not exacerbate Seneca Valley virus infection in nursery-age pigs [PDF]

BMC Veterinary Research, 2018
Senecavirus A, commonly known as Seneca Valley virus (SVV), is a picornavirus that has been infrequently associated with porcine idiopathic vesicular disease (PIVD). In late 2014 there were multiple PIVD outbreaks in several states in Brazil and samples from those cases tested positive for SVV.
Alexandra Buckley, Nestor Montiel, Baoqing Guo, Vikas Kulshreshtha, Albert van Geelen, Hai Hoang, Christopher Rademacher, Kyoung-Jin Yoon, Kelly Lager   +8 more
openaire   +4 more sources