Results 31 to 40 of about 4,708 (179)

Seneca Valley virus 3C protease targets TRIM32 for cleavage to antagonize its antiviral effects. [PDF]

J Virol
The Seneca Valley virus (SVV), a newly emerged virus within the Picornaviridae family, causes porcine idiopathic vesicular disease, imposing substantial economic costs to the global pork industry.
Yang J, Li Z, Ma R, Xie S, Wang D, Quan R, Liu J, Song J.   +7 more
europepmc   +2 more sources

Species-specific IL-1β is an inflammatory sensor of Seneca Valley Virus 3C Protease. [PDF]

PLoS Pathog
Inflammasomes play pivotal roles in inflammation by processing and promoting the secretion of IL-1β. Caspase-1 is involved in the maturation of IL-1β and IL-18, while human caspase-4 specifically processes IL-18.
Huang X, Zhao Z, Zhu C, Chai L, Yan Y, Yuan Y, Wu L, Li M, Jiang X, Wang H, Liu Z, Li P, Li X.   +12 more
europepmc   +2 more sources

Seneca Valley virus 3C protease targets the Nrf2/HO-1 pathway to antagonize its antiviral activity. [PDF]

J Virol
Seneca Valley virus (SVV) infection gives rise to severe vesicular diseases in pigs, presenting a substantial threat to the global swine industry. The redox imbalance resulting from oxidative stress is an essential pathogenic mechanism during viral ...
Song J, Liu T, Yang J, Zhao L, Su J, Li Z, Ma R, Wen X, Cheng P.   +8 more
europepmc   +2 more sources

Buffalo-Origin Seneca Valley Virus in China: First Report, Isolation, Genome Characterization, and Evolution Analysis. [PDF]

Front Vet Sci, 2021
Pigs are the main host of Seneca Valley virus (SVV), previously known as Senecavirus A (SVA). Pigs affected by SVV have vesicles in the nose, hooves, and limp and may cause death in some severe cases.
Zhou X, Liang WF, Si GB, Li JH, Chen ZF, Cai WY, Lv DH, Wen XH, Zhai Q, Zhai SL, Liao M, He DS.   +11 more
europepmc   +2 more sources

Oncolytic Seneca Valley Virus: past perspectives and future directions

Oncolytic Virotherapy, 2016
Seneca Valley Virus isolate 001 (SVV-001) is an oncolytic RNA virus of the Picornaviridae family. It is also the first picornavirus discovered of the novel genus Senecavirus. SVV-001 replicates through an RNA intermediate, bypassing a DNA phase, and is unable to integrate into the host genome.
Michael J Burke
openaire   +6 more sources

N-Linked Glycosylation on Anthrax Toxin Receptor 1 Is Essential for Seneca Valley Virus Infection. [PDF]

Viruses, 2021
Seneca Valley virus (SVV) is a picornavirus with potency in selectively infecting and lysing cancerous cells. The cellular receptor for SVV mediating the selective tropism for tumors is anthrax toxin receptor 1 (ANTXR1), a type I transmembrane protein ...
Jayawardena N, Miles LA, Burga LN, Rudin C, Wolf M, Poirier JT, Bostina M.   +6 more
europepmc   +2 more sources

Mfn2 is responsible for inhibition of the RIG-I/IRF7 pathway and activation of NLRP3 inflammasome in Seneca Valley virus-infected PK-15 cells to promote viral replication. [PDF]

Front Immunol, 2022
Seneca Valley virus (SVV), a non-enveloped positive single-stranded virus can cause vesicular disease in swine. However, the mechanisms by which SVV activates an innate immune response remain unknown.
Deng H, Zhu S, Zhu L, Sun J, Ding Y, Li F, Jian Z, Zhao J, Deng L, Deng J, Deng Y, Guo H, Sun X, Lai SY, Tang H, Cui H, Ge LP, Xu Z.   +17 more
europepmc   +2 more sources

Identification of a conserved neutralizing epitope in Seneca Valley virus VP2 protein: new insight for epitope vaccine designment. [PDF]

Virol J, 2022
Background Seneca Valley virus (SVV) is a picornavirus that causes vesicular disease in swine. Clinical characteristics of the disease are similar to common viral diseases such as foot-and-mouth disease virus, porcine vesicular disease virus, and ...
Wen W, Chen X, Lv Q, Chen H, Qian P, Li X.   +5 more
europepmc   +2 more sources

Isolation and Characterization of Seneca Valley Virus From Pig Transboundary Spread to the Mink Infection. [PDF]

Transbound Emerg Dis
Seneca Valley virus (SVV) infection has recently disseminated across pig farms in Canada, America, and China. The SVV has been identified in humans, rodents, and houseflies. Although cross‐species transmission events may lead to limited subsequent transmission, sustained outbreaks have been observed in new mammalian hosts.
Qin Z, He X, Chen C, Chen S, Nai Z, Wang Y, Wang W, Li G, Wang F, Tian M, He H, Chen H, Liu D, Jiang X.   +13 more
europepmc   +2 more sources

Evolutionary dynamics and adaptive analysis of Seneca Valley virus

Infection, Genetics and Evolution, 2023
Over the past 20 years, the Seneca Valley virus (SVV) has emerged in various countries and regions around the world. Infected pigs display symptoms similar to foot-and-mouth disease and other vesicular diseases, causing severe economic losses to affected countries.
Weijun, Zeng, Quanhui, Yan, Pengfei, Du, Zhongmao, Yuan, Yawei, Sun, Xiaodi, Liu, Lihong, Zhang, Xueyi, Liu, Hongxing, Ding, Lin, Yi, Shuangqi, Fan, Jinding, Chen, Mingqiu, Zhao   +12 more
openaire   +2 more sources