Results 71 to 80 of about 4,708 (179)

Extracellular vesicles promote the infection and pathogenicity of Japanese encephalitis virus

Journal of Extracellular Vesicles, Volume 14, Issue 1, January 2025.
Abstract Japanese encephalitis virus (JEV) is a neurotropic zoonotic pathogen that poses a serious threat to public health. Currently, there is no specific therapeutic agent available for JEV infection, primarily due to the complexity of its infection mechanism and pathogenesis.
Junyao Xiong, Ling'en Yang, Xiaowei Nan, Shuo Zhu, Mengxue Yan, Shengxian Xiang, Luping Zhang, Qi Li, Chengjie Yang, Xugang Wang, Ning Wei, Huanchun Chen, Youhui Si, Shengbo Cao, Jing Ye   +14 more
wiley   +1 more source

A Non-Nucleotide STING Agonist MSA-2 Synergized with Manganese in Enhancing STING Activation to Elicit Potent Anti-RNA Virus Activity in the Cells

Viruses, 2023
Both Manganese (Mn2+) and MSA-2 can activate the downstream signal pathway through stimulator of interferon genes (STING) and induce the expression of type I interferon, which is important for hosts to protect against DNA viruses.
Hanrui Lin, Rui Zhang, Hanyi Xiang, Xinqian Lin, Xiongting Huang, Jingsong Chen, Long Zhou, Zhidong Zhang, Yanmin Li   +8 more
doaj   +1 more source

Multiorgan proteomic analysis of infected animal models predict potential host factors for chikungunya virus

MedComm, Volume 6, Issue 1, January 2025.
We depicted the multiorgan proteomic landscape in CHIKV‐infected animal models, revealing the potential role of the RLR signaling pathway against CHIKV infection and dysregulated metabolism. Moreover, we predicted potential host factors contributing to organ‐specific inflammation and hemorrhage in rhesus monkeys through bioinformatic and correlation ...
Dongdong Lin, Cong Tang, Junbin Wang, Yun Yang, Hao Yang, Yanan Zhou, Wenhai Yu, Bai Li, Qing Huang, Haixuan Wang, Ran An, Xiaoming Liang, Yuhuan Yan, Longhai Yuan, Xuena Du, Yuxia Yuan, Yanwen Li, Shuaiyao Lu   +17 more
wiley   +1 more source

Clinical Manifestations of Senecavirus A Infection in Neonatal Pigs, Brazil, 2015

Emerging Infectious Diseases, 2016
We identified new clinical manifestations associated with Senecavirus A infection in neonatal piglets in Brazil in 2015. Immunohistochemical and molecular findings confirmed the association of Senecavirus A with these unusual clinical signs and more ...
Raquel A. Leme, Thalita E.S. Oliveira, Brígida K. Alcântara, Selwyn A. Headley, Alice F. Alfieri, Ming Yang, Amauri A. Alfieri   +6 more
doaj   +1 more source

Epitope Mapping of Senecavirus A 3A Protein Using Monoclonal Antibodies

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Senecavirus A (SVA), an emerging pathogen causing vesicular disease in pigs, poses a significant threat to the swine industry. The nonstructural protein 3A of SVA plays an essential role in the viral replication cycle. In this study, we immunized mice with the prepared SVA 3A protein and produced two monoclonal antibodies (mAbs), AG4 and 2F3.
Liang Meng, Xiao-Xiao Tian, Xu-Yan Xiang, Xin-Yu Qi, Han-Rong Zhou, Pei-Yu Xiao, Tong-Qing An, Fan-Dan Meng, Hai-Wei Wang, Zongfu Wu   +9 more
wiley   +1 more source

Seneca Valley Virus 3Cpro Substrate Optimization Yields Efficient Substrates for Use in Peptide-Prodrug Therapy. [PDF]

PLoS ONE, 2015
The oncolytic picornavirus Seneca Valley Virus (SVV-001) demonstrates anti-tumor activity in models of small cell lung cancer (SCLC), but may ultimately need to be combined with cytotoxic therapies to improve responses observed in patients. Combining SVV-
Linde A Miles, W Nathaniel Brennen, Charles M Rudin, John T Poirier   +3 more
doaj   +1 more source

LncRNA 8244-ssc-miR-320-CCR7 Regulates IFN-β during SVA Infecting PK-15 Cells

Microorganisms, 2023
Seneca Valley virus (SVV), a member of the Picornaviridae family, is an oncolytic RNA virus that can cause idiopathic vesicular disease and increase mortality in newborn piglets.
Xiaoyu Tang, Ruiyu Zhang, Long Gao, Xiaocheng Lv, Yuan Sun, Jingyun Ma   +5 more
doaj   +1 more source

Modeling the transboundary risk of feed ingredients contaminated with porcine epidemic diarrhea virus [PDF]

, 2016
Citation: Dee, S., Neill, C., Singrey, A., Clement, T., Cochrane, R., Jones, C., . . . Nelson, E. (2016). Modeling the transboundary risk of feed ingredients contaminated with porcine epidemic diarrhea virus. Bmc Veterinary Research, 12, 12.
Christopher-Hennings, J., Clement, T., Cochrane, R., Dee, S., Jones, Cassandra K., Neill, C., Nelson, E., Patterson, G., Singrey, A., Spronk, G.   +9 more
core   +1 more source

Targeting GBM With an Oncolytic Picornavirus Svv-001 Alone and in Combination With Fractionated Radiation in a Novel Panel of Orthotopic PDX Models [PDF]

, 2023
BACKGROUND: Animal models representing different molecular subtypes of glioblastoma multiforme (GBM) is desired for developing new therapies. SVV-001 is an oncolytic virus selectively targeting cancer cells.
Abdallah, Aalaa, Ahmed, Nabil M, Baxter, Patricia A, Brat, Daniel J, Braun, Frank K, Du, Yuchen, Hellenbeck, Paul L, Huang, Frank, Huang, Yulun, Karthick, Sekar, Kogiso, Mari, Li, Xiao-Nan, Patel, Akash J, Qi, Lin, Salsman, Vita S, Su, Jack M, Suarez, Milagros, Teo, Wan-Yee, Xiao, Sophie, Zhang, Huiyuan   +19 more
core   +2 more sources

Seneca valley virus activates autophagy through the PERK and ATF6 UPR pathways

Virology, 2019
Diverse effects on autophagy, a cell degradation pathway, have been associated with the infectious mechanisms of different pathogens. Here, we demonstrated that Seneca valley virus (SVV), an important emerging porcine virus characterized by vesicular lesions and neonatal mortality, can induce autophagy in cultured PK-15 and BHK-21 cells by detecting ...
Lei, Hou, Jianguo, Dong, Shanshan, Zhu, Feng, Yuan, Li, Wei, Jing, Wang, Rong, Quan, Jun, Chu, Dan, Wang, Haijun, Jiang, Yanyang, Xi, Zixuan, Li, Huiqi, Song, Yuxin, Guo, Moran, Lv, Jue, Liu   +15 more
openaire   +2 more sources