Results 1 to 10 of about 888 (135)

Epitope Mapping of <i>Senecavirus A</i> 3A Protein Using Monoclonal Antibodies. [PDF]

Transbound Emerg Dis
Senecavirus A (SVA), an emerging pathogen causing vesicular disease in pigs, poses a significant threat to the swine industry. The nonstructural protein 3A of SVA plays an essential role in the viral replication cycle. In this study, we immunized mice with the prepared SVA 3A protein and produced two monoclonal antibodies (mAbs), AG4 and 2F3.
Meng L, Tian XX, Xiang XY, Qi XY, Zhou HR, Xiao PY, An TQ, Meng FD, Wang HW.   +8 more
europepmc   +4 more sources

Phylogeographic Characterizations of Recent (2015-2023) Senecavirus A Isolates from Canada. [PDF]

Viruses
Senecavirus A (SVA) continues to cause vesicular lesions in swine in Canada and many regions worldwide. Since the vesicular lesions caused by SVA are similar to those caused by foot and mouth disease virus, swine vesicular disease virus and vesicular ...
Hole K, Vernygora O, Handel K, Nebroski M, Lung O, Nfon C, Babiuk S.   +6 more
europepmc   +4 more sources

Development of a CRISPR/Cas12a-based fluorescent detection method of Senecavirus A. [PDF]

BMC Vet Res
Background Senecavirus A (SVA), identified in 2002, is known to cause porcine idiopathic vesicular disease (PIVD), which presents with symptoms resembling other vesicular diseases. This similarity complicates field diagnosis.
He W, Liao K, Li R, Peng W, Qian B, Zeng D, Tang F, Xue F, Jung YS, Dai J.   +9 more
europepmc   +4 more sources

Phorbol Myristate Acetate Inhibits Senecavirus A Replication by Activating IKBKE-Mediated IFN Pathway and NF-κB Signal. [PDF]

Transbound Emerg Dis
Senecavirus A (SVA) is an emerging picornavirus causing vesicular disease indistinguishable from foot‐and‐mouth disease virus (FMDV). So far, there are no commercial vaccines and effective therapeutic drugs against SVA infection in China. Here, a library of 112 compounds were screened, and we found that phorbol myristate acetate plays an antagonistic ...
Yan J, Gao Y, Guo C, Dong Y, Jiang P, Bai J.   +5 more
europepmc   +2 more sources

Establishment and Application of a Novel Protein Microarray for Serological Detection and Differentiation of Senecavirus A. [PDF]

Transbound Emerg Dis
Senecavirus A (SVA) is an emerging swine pathogen that causes vesicular disease, which presents clinically indistinguishable signs from other vesicular diseases. To enable differentiation of infected from vaccinated animals (DIVA), we developed a novel protein microarray for dual serological detection of antibodies against SVA structural (VP2‐VP3‐VP1 ...
Li D, Deng J, Wang Z, Zhang Y, Li Y, Hao L, Tian K, Li X.   +7 more
europepmc   +2 more sources

Global Phosphoproteomics Analysis of IBRS-2 Cells Infected With Senecavirus A [PDF]

Frontiers in Microbiology, 2022
Phosphorylation is a widespread posttranslational modification that regulates numerous biological processes. Viruses can alter the physiological activities of host cells to promote virus particle replication, and manipulating phosphorylation is one of ...
Jieyi Li, Zhongwang Zhang, Zhongwang Zhang, Jianliang Lv, Jianliang Lv, Zhongyuan Ma, Li Pan, Li Pan, Yongguang Zhang, Yongguang Zhang   +9 more
doaj   +3 more sources

The Evolution and Global Spatiotemporal Dynamics of Senecavirus A

Microbiology Spectrum, 2022
Recurrent outbreaks of senecavirus A (SVA)-associated vesicular disease have led to a large number of infected pigs being culled and has caused considerable economic losses to the swine industry. Although SVA was discovered 2 decades ago, knowledge about
Huiguang Wu, Chen Li, Yongchen Ji, Chunxiao Mou, Zhenhai Chen, Jingwen Zhao   +5 more
doaj   +3 more sources

Indirect ELISA Using Multi-Antigenic Dominants of VP1, VP2, and VP3 Recombinant Protein to Detect Antibodies Against Senecavirus A in Pigs. [PDF]

Vet Sci
Senecavirus A (SVA) is an emerging pathogen that poses a significant threat to the global swine industry. With the advent of SVA vaccines, there is a growing need to develop serological diagnostic methods for evaluating vaccine-induced immunity.
Wang Z, Li D, Li Y, Zhang Y, Deng J, Hao L, Tian K, Li X.   +7 more
europepmc   +2 more sources

Differential roles of HSP70 and HSP90 in Senecavirus A infection: IRES-dependent translational regulation and viral replication mechanisms. [PDF]

Virulence
As opportunistic intracellular pathogens, viruses rely on numerous sequential interactions between host and viral factors for their replication. Given the significance of molecular chaperones (heat shock protein 70 and heat shock protein 90) in mediating
Li C, Ma Y, Liu C, Xu S, Shi J, Li J.
europepmc   +2 more sources

Evolutionary characterization and pathogenicity of Senecavirus isolated from Shandong, China. [PDF]

Virus Res
Senecavirus A (SVA), previously called Seneca Valley virus, belongs to the family Picornaviridae, species Senecavirus A, in the Senecavirus genus. SVA infection causes vesicular lesions in sows and a sharp drop in neonatal piglet production.
Dong Y, Wen J, Guo C, Li J, Yan J, Li M, Jiang T, Gao Y, Wang X, Jiang P, Bai J.   +10 more
europepmc   +2 more sources