Results 31 to 40 of about 1,525 (194)

VP0 Myristoylation Is Essential for Senecavirus A Replication

Pathogens
Many picornaviruses require the myristoylation of capsid proteins for viral replication. Myristoylation is a site-specific lipidation to the N-terminal G residue of viral proteins, which is catalyzed by the ubiquitous eukaryotic enzyme N ...
Peiyu Xiao, Liang Meng, Xingyang Cui, Xinran Liu, Lei Qin, Fandan Meng, Xuehui Cai, Dongni Kong, Tongqing An, Haiwei Wang   +9 more
doaj   +3 more sources

TRIM5 inhibits the replication of Senecavirus A by promoting the RIG-I-mediated type I interferon antiviral response. [PDF]

Vet Res
Senecavirus A (SVA) is an emerging virus that poses a threat to swine herds worldwide. To date, the role of tripartite motif 5 (TRIM5) in the replication of viruses has not been evaluated.
Li H, Xie Z, Lei X, Chen M, Zheng T, Lin C, Ning Z.   +6 more
europepmc   +2 more sources

Infectious recombinant Senecavirus A expressing novel reporter proteins [PDF]

Applied Microbiology and Biotechnology, 2021
Senecavirus A (SVA) is an emerging picornavirus that has been associated with vesicular disease and neonatal mortality in swine. The construction of SVA virus carrying foreign reporter gene provides a powerful tool in virus research. However, it is often fraught with rescuing a recombinant picornavirus harboring a foreign gene or maintaining the ...
Minmin Wang, Chunxiao Mou, Mi Chen, Zhenhai Chen   +3 more
openaire   +2 more sources

Comparative transcriptomics analysis on Senecavirus A-infected and non-infected cells. [PDF]

Front Vet Sci
Senecavirus A (SVA) is an emerging virus that causes the vesicular disease in pigs, clinically indistinguishable from other high consequence vesicular diseases. This virus belongs to the genus Senecavirus in the family Picornaviridae. Its genome is a positive-sense, single-stranded RNA, approximately 7,300 nt in length, with a 3′ poly(A) tail but ...
Li Y, Chu H, Jiang Y, Li Z, Wang J, Liu F.   +5 more
europepmc   +4 more sources

A virulent and pathogenic infectious clone of Senecavirus A [PDF]

Journal of General Virology, 2021
Senecavirus A (SVA) is a picornavirus that circulates in swine populations worldwide causing vesicular disease (VD) in affected animals. Here we developed a reverse genetics system for SVA based on the well-characterized wild-type SVA strain SD15-26 (wt SVA SD15-26). The full-length cDNA genome of SVA was cloned into a plasmid under a T7 RNA polymerase
Maureen H. V. Fernandes, Marcelo de Lima, Lok R. Joshi, Diego G. Diel   +3 more
openaire   +2 more sources

Infectious Recombinant Senecavirus A Expressing p16INK4A Protein

International Journal of Molecular Sciences, 2023
Senecavirus A (SVA) is an oncolytic RNA virus, and it is the ideal oncolytic virus that can be genetically engineered for editing. However, there has not been much exploration into creating SVA viruses that carry antitumor genes to increase their oncolytic potential.
Gong, Wencheng, Zhao, Xiaoya, Tang, Xiaoyu, Gao, Long, Sun, Yuan, Ma, Jingyun   +5 more
openaire   +2 more sources

Senecavirus A: Frequently asked questions

Journal of Swine Health and Production, 2022
Senecavirus A (SVA) has been demonstrated to be a causative agent for vesicular disease in swine. It is clinically indistinguishable from other agents that cause vesicular disease such as foot-and-mouth disease virus (FMDV), which is a reportable foreign animal disease (FAD).
Alexandra Buckley, Kelly Lager
openaire   +1 more source

Senecavirus A [PDF]

Veterinary Pathology, 2016
Senecavirus A (SVA) is the only member of the genus Senecavirus within the family Picornaviridae. This virus was discovered as a serendipitous finding in 2002 (and named Seneca Valley virus 001 [SVV-001]) while cultivating viral vectors in cell culture and has been proposed for use as an oncolytic virus to treat different types of human neoplasia. SVA
J. Segalés, D. Barcellos, A. Alfieri, E. Burrough, D. Marthaler   +4 more
openaire   +1 more source

Experimental Senecavirus A Infection of Bovine Cell Lines and Colostrum-Deprived Calves

Viruses, 2022
Senecavirus A (SVA) is a causative agent for vesicular disease in swine, which is clinically indistinguishable from other vesicular diseases of swine including foot-and-mouth disease (FMD).
Alexandra Buckley, Lauren Crawford, Kyle Hoffman, Shollie Falkenberg   +3 more
doaj   +1 more source

Construction of eGFP-Tagged Senecavirus A for Facilitating Virus Neutralization Test and Antiviral Assay

Viruses, 2020
Senecavirus A (SVA), also known as Seneca Valley virus, is an emerging virus that causes vesicular disease in pigs. This virus belongs to the genus Senecavirus in the family Picornaviridae.
Fuxiao Liu, Yilan Huang, Qianqian Wang, Hu Shan   +3 more
doaj   +1 more source