Determination of Senegenin and Tenuifolin in Mouse Blood by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry and Their Pharmacokinetics [PDF]
International Journal of Analytical Chemistry, 2022 An ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the determination of senegenin and tenuifolin in mouse blood was developed.
Xiuwei Shen +4 more
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Senegenin Attenuates Pulmonary Fibrosis by Inhibiting Oxidative-Stress-Induced Epithelial Cell Senescence through Activation of the Sirt1/Pgc-1α Signaling Pathway [PDF]
AntioxidantsIdiopathic pulmonary fibrosis is a fatal interstitial lung disease for which effective drug therapies are lacking. Senegenin, an effective active compound from the traditional Chinese herb Polygala tenuifolia Willd, has been shown to have a wide range of
Ziqiang Luo, Wei Liu, Zhengang Hu
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Senegenin inhibits neuronal apoptosis after spinal cord contusion injury [PDF]
Neural Regeneration Research, 2016 Senegenin has been shown to inhibit neuronal apoptosis, thereby exerting a neuroprotective effect. In the present study, we established a rat model of spinal cord contusion injury using the modified Allen′s method. Three hours after injury, senegenin (30
Jin-Lan Jiang +2 more
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Neuroprotective Effects and Mechanisms of Senegenin, an Effective Compound Originated From the Roots of Polygala Tenuifolia [PDF]
Frontiers in Pharmacology, 2022 Senegenin is the main bioactive ingredient isolated from the dried roots of Polygala tenuifolia Willd. In recent years, senegenin has been proved to possess a variety of pharmacological activities, such as anti-oxidation, anti-inflammation, anti ...
Zhe Chen, Yu Yang, Ying Han, Xijun Wang
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Avicularin and Senegenin Suppress TRPV3-Associated TSLP Expression in Human Keratinocytes [PDF]
CellsTransient receptor potential vanilloid channel 3 (TRPV3) is a keratinocyte-expressed ion channel that regulates calcium signaling and thymic stromal lymphopoietin (TSLP) production, contributing to pruritic inflammatory skin diseases. Although avicularin
Han Bi Kim +5 more
doaj +3 more sources
Senegenin Attenuates Hepatic Ischemia-Reperfusion Induced Cognitive Dysfunction by Increasing Hippocampal NR2B Expression in Rats [PDF]
PLoS ONE, 2012 BACKGROUND: The root of Polygala tenuifolia, a traditional Chinese medicine, has been used to improve memory and intelligence, while the underlying mechanisms remain largely unknown.
Yu-E Sun
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Polygala tenuifolia: a source for anti-Alzheimer’s disease drugs [PDF]
Pharmaceutical Biology, 2020 Context Alzheimer’s disease (AD) is a chronic neurodegenerative disease that originates from central nervous system lesions or recessions. Current estimates suggest that this disease affects over 35 million people worldwide.
Xinxin Deng +8 more
doaj +2 more sources
Propofol exposure during early gestation impairs learning and memory in rat offspring by inhibiting the acetylation of histone. [PDF]
J Cell Mol Med, 2018 Abstract Propofol is widely used in clinical practice, including non‐obstetric surgery in pregnant women. Previously, we found that propofol anaesthesia in maternal rats during the third trimester (E18) caused learning and memory impairment to the offspring rats, but how about the exposure during early pregnancy and the underlying mechanisms?
Lin J +6 more
europepmc +2 more sources
Mechanisms of Senegenin in Regulating Oxidative Stress and Mitochondria Damage for Neuroprotection in Insomnia: Evidence from In Vivo and In Vitro Models [PDF]
Molecular NeurobiologyXingping Zhang, Deqi Yan
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Senegenin regulates the mechanism of insomnia through the Keap1/Nrf2/PINK1/Parkin pathway mediated by GAD67 [PDF]
Journal of Sleep ResearchXingping Zhang
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