Results 11 to 20 of about 176 (85)

Senegenin Inhibits Aβ_1-42-Induced PC12 Cells Apoptosis and Oxidative Stress via Activation of the PI3K/Akt Signaling Pathway. [PDF]

Neuropsychiatr Dis Treat, 2022
Ren X, Zhang J, Zhao Y, Sun L.
europepmc   +2 more sources

Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and Strokes

Advanced Science, Volume 10, Issue 24, August 25, 2023., 2023
The roles of ferroptosis contributing to neurodegenerative diseases and strokes are described, and the emerging data in treating these diseases through pharmacological inhibition of ferroptosis, highlighting a potential promising therapeutic avenue that could be used to prevent neurodegenerative diseases and strokes are summarized.
Yumin Wang, Shuang Wu, Qiang Li, Huiyan Sun, Hongquan Wang   +4 more
wiley   +1 more source

Comparative Study on the Chemical Components and Gastrointestinal Function on Rats of the Raw Product and Licorice‐Simmered Product of Polygala tenuifolia

Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021
The root of Polygala tenuifolia Willd. (Polygalaceae) (PT) has been listed as a nootropic, anti‐inflammatory, and antipsychotic medicine that can cure insomnia. Raw PT (RPT) is toxic and must be processed before clinical use. Licorice‐simmered PT (LPT) is one of the most common processed products.
Yueli Cui, Xin Zhao, Yuqiu Tang, Yanxue Zhang, Le Sun, Xuelan Zhang, Letizia Angiolella   +6 more
wiley   +1 more source

A dual fluorescence reporter system for high throughput screening of effectors of Kiss1 gene expression

FEBS Open Bio, Volume 8, Issue 8, Page 1352-1363, August 2018., 2018
An in vitro dual fluorescence reporter system was constructed for high throughput screening of effectors influencing Kiss1 expression. In GT1‐7 cells, enhanced GFP was placed under the control of the Kiss1 regulatory elements by inserting it in‐frame with Kiss1. A tdTomato gene cassette was introduced into the same cell.
Xiaoning Li, Sijia Wang, Yanhua Lu, Huanhuan Yin, Junhua Xiao, Kai Li, Lei Ma, Yuxun Zhou   +7 more
wiley   +1 more source

The Gastrointestinal Irritation of Polygala Saponins and Its Potential Mechanism In Vitro and In Vivo

BioMed Research International, Volume 2015, Issue 1, 2015., 2015
Processing alters the pharmacological activity and reduces the gastrointestinal toxicity of the polygalae. To investigate the effect of processing, different glycosyl substituent products were tested. Hypnotic and subhypnotic doses of pentobarbital‐induced sleep tests on mice were used to evaluate the sedative activity of polygala saponins with ...
Li Wen, Nan Xia, PeiPei Tang, Yi Hong, ZiZhen Wang, YaJie Liu, YanJu Liu, JianJun Liu, XiangQiong Li, Dimitrios P. Bogdanos   +9 more
wiley   +1 more source

Senegenin Inhibits Aβ1-42-Induced PC12 Cells Apoptosis and Oxidative Stress via Activation of the PI3K/Akt Signaling Pathway

Neuropsychiatric Disease and Treatment, 2022
Xing Ren,1 Jiwei Zhang,2 Yunnan Zhao,3 Lingzhi Sun4 1College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250014, People’s Republic of China; 2College of Acupuncture and Massage, Shandong University of ...
Ren X, Zhang J, Zhao Y, Sun L
doaj  

Onjisaponin B Derived from Radix Polygalae Enhances Autophagy and Accelerates the Degradation of Mutant α-Synuclein and Huntingtin in PC-12 Cells

, 2013
Emerging evidence indicates important protective roles being played by autophagy in neurodegenerative disorders through clearance of aggregate-prone or mutant proteins.
Betty Law, Wai-Kit Chan, Law, Betty, Liu, Liang, Xu, Su-Wei, Su-Wei Xu, Vincent Wong, Liang Liu, Ng, Choi-In, Choi-In Ng, Chan, Wai-Kit, Wu, An-Guo, Wong, Vincent, An-Guo Wu   +13 more
core   +1 more source

Spatial metabolome of Polygala tenuifolia and Polygala sibirica roots by matrix-assisted laser desorption/ionization mass spectrometry imaging

Industrial Crops and Products
The therapeutic efficacy of medicinal plants is intrinsically linked to the spatial distribution of their bioactive constituents, yet this critical aspect has been largely uncharacterized due to technical limitations in metabolite localization.
Yihan Zhu, Jie Shen, Yilei Zhang, Gang Zhang, Jing Gao, Xinjie Yang, Fusheng Zhang, Yonggang Yan, Bingyue Yang, Liang Peng   +9 more
doaj   +1 more source

Effect of senegenin on cognitive deficits induced by hepatic ischemia-reperfusion in rats.

, 2013
A.Mean escape latency in the step-down test of every group at 1 (D1), 3 (D3), 5 (D5), or 7 (D7) day afte operation.B. Number of errors in Y maze test.
Yan Yang (33204), Zhengliang Ma (306283), Xiaoping Gu (306278), Jinhua Bo (306281), Weibin Xie (306277), Yu-e Sun (306280), Ying Liang (13730), Yaguo Zheng (306279)   +7 more
core   +1 more source

The mechanism study of the effect of senegenin on hepatocellular carcinoma by regulating the level of O-GlcNAc glycosylation

Hepatocellular carcinoma (HCC) is a condition with numerous etiologies and risk factors, according to the studies that are currently available. The pathogenesis of HCC remains to be studied.
Liu, Zhiyong
core   +1 more source