Results 101 to 110 of about 1,611 (231)

Iron Deficiency in Heart Failure with Reduced Ejection Fraction: Pathophysiology, Diagnosis and Treatment. [PDF]

Arq Bras Cardiol, 2022
Pereira GAR, Beck-da-Silva L.
europepmc   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Estudio de células senescentes por citometría de imagen [PDF]

, 2019
La senescencia celular, conocida como la detención irreversible de la división celular, puede ser inducida por agentes oxidantes y radiación ultravioleta entre otros.
Pereboom Maicas, Desirée, Alda Torrubia, José Octavio, Navarro Amesti, Jorge   +2 more
core  

Reabsorção de nutrientes por espécies arbóreas acumuladoras de fósforo na Amazônia: influência na qualidade da serrapilheira.

Revista Brasileira de Agroecologia, 2009
A importância de se conhecer as concentrações e os estoques de nutrientes como o fósforo (P) e o nitrogênio (N) na serrapilheira (liteira) produzida por espécies potencialmente acumuladoras de fósforo em florestas secundárias cujos solos são deficientes
Patricia Chaves de Oliveira, Claudio José Reis de Carvalho   +1 more
doaj  

Comparison of senescence progression in mesenchymal cells from human umbilical cord walls measured by immunofluorescence and flow cytometry of p16 and p21. [PDF]

Einstein (Sao Paulo), 2020
Silva AD, Piccinato CA, Sardinha LR, Sardinha LR, Aloia TPA, Goldberg AC.   +5 more
europepmc   +1 more source

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

Factores locales y su relación con lesiones bucales en ancianos portadores de prótesis totales

Medisan
Se realizó un estudio descriptivo y transversal de 96 senescentes portadores de prótesis totales, atendidos en la Clínica Estomatológica "Lidia Doce Sánchez" de Guantánamo, desde enero de 2014 hasta abril de 2015, con vistas a determinar la relación ...
Marcia Hortensia Corona Carpio, Ana Duharte Escalante, Josefa Navarro Nápoles, Ruth Ramón Jiménez, Lizel Díaz del Mazo   +4 more
doaj  

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

Transcriptoma diferencial entre células-tronco mesenquimais humanas jovens e senescentes [PDF]

, 2013
Human mesenchymal stem cells (MSC) are powerful sources for cell therapy in regenerative medicine. The long time cultivation can result in replicative senescence or can be related to the emergence of chromosomal alterations responsible for the ...
Tavares, Joana Cristina Medeiros
core