Results 121 to 130 of about 1,611 (231)

Estado nutricional del paciente geriátrico hospitalizado.

Gaceta Médica Espirituana, 2012
La edad se acompaña de una serie de circunstancias fisiológicas, económicas y sociales que contribuyen a afectar de una manera adversa el estado nutricional de la población anciana, la hospitalización es una de ellas. El objetivo de la investigación fue
Tamara Álvarez Gómez, Jorge Enrique Izquierdo Paz, Marisel de la C. Valdes Mijares, Cristina Cabrera Cabrera, Ricardo E. Amurrio Flores, Edwin Giovany Ortiz Rojas   +5 more
doaj  

Restoring Endothelial Mitochondrial Homeostasis With a Bioactive Nanoshield Promotes Vascular Regeneration on Cardiovascular Implants

Advanced Science, EarlyView.
A bioactive poly(citrate‐polyglycol‐procyanidin) (PCGP) nanoshield is developed for cardiovascular implants to restore endothelial mitochondrial homeostasis following vascular injury. By preserving mitochondrial integrity, re‐establishing metabolic balance, and activating PI3K/Akt/eNOS‐NO signaling, the PCGP interface promotes functional endothelial ...
Xiyu Liu, Wen Zhang, Lunxin Liu, Lan Gui, Yumei Qin, Xiaohui Yang, Longjian Zhang, Chaohua Wang, Jinpeng Hu, Gaoyang Guo, Qing Jiang, Jin Wang, Li Yang, Bo Zhang, Yunbing Wang   +14 more
wiley   +1 more source

Modelo lineal para la predicción del daño producido por impacto mecánico en pera blanquilla. [PDF]

, 1988
Frutos de pera cv. "Blanquilla" de distintos grados de madurez se ensayaron a impacto mecánico con un indentador esférico de 50.6 g de masa desde tres alturas de caída ( 4,6 y 10 cm) y se determinó un modelo lineal para cada uno de los parámetros que ...
Rodríguez Sinobas, Leonor, Ruiz-Altisent, Margarita   +1 more
core  

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

Advanced Science, EarlyView.
Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu, Renxian Wang, Dingding Wang, Quanzhong Ren, Ling Wang, Fangfang Duan, Guihe Yang, Ruixuan Yu, Yi Wang, Yingyu Zhang, Zetong Zang, Chuqi Li, Weijia Liu, Wenshuang Zhang, Yi Yuan, Zitong Cheng, Xiaoguang Cheng, Junbo Liang, Yajun Liu   +18 more
wiley   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

RBM25 Drives Hepatocellular Carcinoma Progression by Stabilizing YAP Through Regulating Oncogenic Splicing‐switch of MYPT1

Advanced Science, EarlyView.
This study establishes that the RBM25‐PRPF40A interaction modulates MYPT1 splicing, promoting the production of the oncogenic long isoform. This isoform stabilizes YAP by suppressing its phosphorylation and subsequent proteasomal degradation, ultimately accelerating tumor growth.
Wenjing Zhang, Lili Zhi, Tian Huang, Lingya Feng, Chaoqun Chen, Huanhuan Wei, Xiaolong Liu, Lei Chen, Jinrui Zhang, Ge Zhang, Baofeng Zhao, Rong Liu, Dan Chen, Yangfan Qi, Yang Wang   +14 more
wiley   +1 more source

Comportamiento de la violencia intrafamiliar en el adulto mayor

Archivo Médico de Camagüey, 2009
Fundamento: la prevención de la violencia en su marco general y familiar es una prioridad que exige un conocimiento exhaustivo de su magnitud; ya que es observada como un asunto de salud pública por su impacto negativo en la sociedad.
Lourdes Docampo Santaló, Rita Barreto Lacaba, Caridad Santana Serrano   +2 more
doaj  

PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling

Advanced Science, EarlyView.
PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu, Zitian Zheng, Feiran Wang, Huanhuan Luo, Fei Ju, Yucheng Zhu, Zheng Zhou, Jie Sun, Zhenghui Qiu, Xiang Luo, Zhongzheng Jia, Jianquan Wang, Hongjie Huang, Bo Zhang   +13 more
wiley   +1 more source

Novas intervenções farmacológicas para a eliminação de células senescentes

Tese de Programa de Doutoramento em Ciências da Saúde apresentada à Faculdade de MedicinaAging is a major predictor of age-related diseases, such as cardiovascular disorders and neurodegeneration.
Aires, Helena Isabel Reis
core  

Avaliação da fenologia das cultivares de macieira Imperatriz, Imperatriz Gala e Fuji em pomar em Bom Retiro – SC

Biotemas, 2007
O trabalho foi realizado em um pomar localizado em Bom Retiro, Santa Catarina. O objetivo foi realizar um estudo fenológico das cultivares Imperatriz, Imperatriz Gala e Fuji, produzidas no pomar e suas relações com a condução do pomar, polinização e ...
Maria Tereza Bolzon Soster, Ana Frederica Latorre   +1 more
doaj