Results 131 to 140 of about 1,611 (231)

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source

Estratégias Farmacológicas para Detectar Células Senescentes

Tese de Doutoramento em Ciências Farmacêuticas apresentada à Faculdade de FarmáciaAging is a major risk factor for the development of age-related diseases, including cardiovascular and neurovascular disorders.
Ribeiro, Inês Tomé
core  

Factores determinantes de un aumento de afinidad al oxígeno aparente en los eritrocitos humanos senescentes

, 2004
En el presente trabajo se ha re-investigado la vieja interrogante de una posible deficiencia en la liberación de oxígeno por los eritrocitos humanos senescentes, estudiando algunos factores que afectan la afinidad hemoglobina-oxígeno en células ...
Romero, Eneida A., Romero, Pedro J.
core  

Influencia de la Casa de Abuelos sobre el adulto mayor Influence of the Grandparents' house on the elderly

Medisan, 2010
Se realizó una investigación prospectiva de 27 ancianos que acudían diariamente a la Casa de Abuelos del municipio de San Luis en la provincia de Santiago de Cuba, los cuales intervinieron entusiastamente en ejercicios físicos, charlas educativas y ...
Yolaida Ortega Márquez
doaj  

Hierarchical Nanoplatform Integrating Oxidative–Acidic Microenvironment Remodeling and Bone Homeostasis Modulation for Diabetic Bone Defect Therapy

Advanced Science, EarlyView.
A hierarchical CM/LDH nanoplatform integrates ROS‐scavenging Ce‐MOF nanozymes with acid‐neutralizing CaAl‐LDH and is delivered within GelMA hydrogel to diabetic bone defects. By remodeling the oxidative‐acidic microenvironment, preserving mitochondrial homeostasis, and suppressing mtDNA–cGAS–STING inflammatory signaling, CM/LDH reduces proinflammatory ...
Xu Chen, Xingyu Zhu, Zhixin Qiu, Yijia Zhu, Xinhui Zheng, Dongqi Fan, Jinglei Zhan, Congxiu Mao, Ping Ji, Tao Chen, Qingqing He   +10 more
wiley   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Influencia del ejercicio físico desde los Círculos de Abuelos en senescentes diabéticos

, 2012
Fundamento: La inactividad y las alteraciones de la movilidad resultan problemas comunes en la población adulta mayor. Objetivo: determinar la influencia del ejercicio físico en pacientes diabéticos mediante la participación en los círculos de abuelos ...
Santana Rivero, Leidy María, Santana Serrano, Caridad, Bello Calzada, Dalnys, Del Toro Rodríguez, María Ester, Valdés Cervantes, Vilda Magalys   +4 more
core  

[The role of immunosenescence and inflammaging in aging-associated diseases]. [PDF]

Rev Med Inst Mex Seguro Soc
García-de la Rosa MT, Wong-Baeza I, Arriaga-Pizano LA.   +2 more
europepmc   +1 more source

FBP1‐Mediated Compartmentalization of Glycolytic Enzyme Complexes Suppresses PKM2 Function to Ameliorate MASLD Progression

Advanced Science, EarlyView.
In normal hepatocytes, FBP1 forms compartmentalized complexes with PKM2, ENO1, and LDHA independent of its catalytic activity, inhibiting PKM2 activity and restricting excessive glycolysis. During MASLD progression, FBP1 downregulation markedly reduces the abundance of these complexes and releases the “hijacked” glycolytic enzymes, leading to PKM2 ...
Busong Wang, Yiping Tang, Na Li, Xuening Dai, Jing Wu, Bin Xue, Yuxin Chen, Jingzi Zhang, Lingdong Kong, Chaojun Li, Lei Fang   +10 more
wiley   +1 more source