Results 141 to 150 of about 1,611 (231)

Identificação de polímeros senolíticos em células senescentes vasculares humanas

Dissertação de Mestrado em Biologia Celular e Molecular apresentada à Faculdade de Ciências e TecnologiaSenescência celular é a incapacidade das células em prosseguir no ciclo celular, permanecendo metabolicamente ativas, mas sendo incapazes de ...
Aires, Helena Isabel Reis
core  

Epigenetic Silencing of CYYR1 Promotes Lung Adenocarcinoma Progression Through TRIM21‐Dependent Regulation of HMMR Stability

Advanced Science, EarlyView.
CYYR1 as an epigenetically dysregulated tumor‐suppressive factor that influences oncoprotein stability through TRIM21‐dependent HMMR regulation and reveals a potential therapeutic vulnerability in CYYR1‐deficient LUAD. The graphical illustration was created using FigDraw (www.figdraw.com).
Fengsheng Dai, Jingyi Tang, Huan Rong, Yu Wang, Xiangyi Zhou, Can Xu, Jianhua Wang, Lili Li, Yue Wu, Fei Deng, Dan Yang, Xiao Yang, Renyan Li, Yongzhong Wu, Dongxi Xiang, Tingxiu Xiang   +15 more
wiley   +1 more source

Diseño racional y caracterización de nanodispositivos de sílice mesoporosa para liberación controlada en células senescentes

, 2017
[ES] La senescencia celular es un estado que se caracteriza por un arresto del ciclo celular permanente y un fenotipo hipersecretor asociado. Originalmente se atribuyó al envejecimiento celular, pero hoy se sabe que puede ser causado por otros.
Blasco Carrasco, Jordi
core  

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

Protective effects of Paeonia suffruticosa callus extract in skin through anti-inflammation and repair UVB-induced damage. [PDF]

Int J Cosmet Sci
Li Y, Han J, Gong R, Liu Y, Zhou Y, Gong T, Wang B, Zhang L, Li S, Chen J.   +9 more
europepmc   +1 more source

Perspectivas de uso de células-tronco em cirurgia vascular. [PDF]

J Vasc Bras, 2016
Bertanha M.
europepmc   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Factors associated with death among hospitalized older adults with COVID-19 in Brazil. [PDF]

Rev Lat Am Enfermagem
Inoue LH, Baccon WC, Marques FRDM, Salci MA, Baldissera VDA, Rossoni SL, Carreira L.   +6 more
europepmc   +1 more source

Tracking CDK1 Dynamics With a Novel Biosensor Mouse and Clinical Cohorts to Predict CDK4/6 Inhibitor Sensitivity in ER+ Breast Cancer

Advanced Science, EarlyView.
Cyclin‐dependent kinase (CDK) 1 activity is a dynamic marker of treatment response in estrogen receptor positive breast cancer. Patient cohorts reveal CDK1 activity increases during progression to invasive disease, where high expression correlates with poor survival. Using a novel Cdk1 biosensor mouse alongside in vitro models, we demonstrate that CDK1
Sarah Alexandrou, Kristine J. Fernandez, Min Li Huang, Ewan K. A. Millar, Claire Vennin, Leila Eshraghi, Tan Dat Timothy Lam, Victoria Lee, Nyah C. Brooks, Janett Stoehr, Cristian Guaman Mendez, Douglas Strathdee, David Stevenson, David Herrmann, Sandra O'Toole, Paul Timpson, Max Nobis, C. Elizabeth Caldon   +17 more
wiley   +1 more source

El bloqueo farmacológico de la interacción entre TMPRSS11A y CD112 favorece el reconocimiento de células senescentes mediada por células mononucleares de sangre periférica humana

La proteasa transmembrana TMPRSS11A pertenece a la familia de serín-proteasas tipo II (TTSP), involucradas en procesos fisiológicos y patológicos como senescencia, reparación tisular y progresión tumoral.
Fernández Cabrera, Christian Daniel
core   +1 more source