Results 41 to 50 of about 1,611 (231)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

Efecto de factores secretados por las células senescentes en la agregación plaquetaria [PDF]

open access: yes, 2016
63 p.Alteraciones de la agregación plaquetaria son frecuentemente observadas en pacientes con cáncer y están asociadas a un mal pronóstico. Se considera que las células tumorales afectan la activación plaquetaria a través de varios mecanismos (1).
Quintanilla Medina, Ricardo Joel   +2 more
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Revisión bibliográfica. Participación de las células senescentes en la patogenia de la aterosclerosis. [PDF]

open access: yes, 2018
53 p.La aterosclerosis es una patología que se caracteriza por el endurecimiento de arterias de mediano y gran calibre, la lesión denominada placa aterosclerótica o ateroma en su forma más avanzada contiene grandes cantidades de células senescentes, pero
Moore Carrasco, Rodrigo (Prof. Guía)   +1 more
core  

Efecto de Navitoclax sobre miofibroblastos cardiacos senescentes [PDF]

open access: yes
El miofibroblasto cardiaco (MFC) es una célula diferenciada proveniente del fibroblasto cardiaco (FC), una célula clave en la regulación de la matriz extracelular (MEC), y este proceso de diferenciación se produce en diferentes patologías y es crucial en
Vélez Hernández, Rubén Andrés
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

Desenvolvimento de angelônia em vaso, sob doses de adubo de liberação lenta

open access: yesOrnamental Horticulture, 2018
Angelonia integerrima é uma espécie nativa que possui potencial ornamental podendo ser cultivada em canteiros, floreiras, vasos, ou ainda ser utilizada como complemento em arranjos florais.
Mara Cíntia Winhelmann   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

¿POR QUÉ ENSEÑAR GERIATRÍA DESDE EL PREGRADO?

open access: yesMedicentro, 2011
El envejecimiento poblacional de la sociedad cubana es una realidad de gran interés por su tendencia al crecimiento. Cuba será, en los próximos cincuenta años, el país del Tercer Mundo más envejecido; alcanzó un 17,0 % de senescentes en el 20091.
Dr. Ángel Isern Menéndez   +1 more
doaj  

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