Bacterial Amyloid and DNA are Important Constituents of Senile Plaques: Further Evidence of the Spirochetal and Biofilm Nature of Senile Plaques. [PDF]
J Alzheimers Dis, 2016 It has long been known that spirochetes form clumps or micro colonies in vitro and in vivo. Cortical spirochetal colonies in syphilitic dementia were considered as reproductive centers for spirochetes. Historic and recent data demonstrate that senile plaques in Alzheimer's disease (AD) are made up by spirochetes.
Miklossy J.
europepmc +7 more sources
Enriched Environment Significantly Reduced Senile Plaques in a Transgenic Mice Model of Alzheimer’s Disease, Improving Memory [PDF]
Frontiers in Aging Neuroscience, 2018 Alzheimer’s disease (AD) is associated with a progressive dementia, and there is good evidence that it is more pronounced in individuals that have fewer stimuli during their lives.
Janaina Balthazar +5 more
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Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum [PDF]
Frontiers in Neuroanatomy, 2017 Genetic variations in the vacuolar protein sorting 10 protein (Vps10p) family have been linked to Alzheimer’s disease (AD). Here we demonstrate deposition of fragments from the Vps10p member sortilin at senile plaques (SPs) in aged and AD human cerebrum.
Xia Hu +17 more
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Ceramides and sphingomyelinases in senile plaques
Neurobiology of Disease, 2014 The senile plaque is a hallmark lesion of Alzheimer disease (AD). We compared, without a priori, the lipidome of the senile plaques and of the adjacent plaque-free neuropil.
Maï Panchal +11 more
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The role of the blood-brain barrier in the pathogenesis of senile plaques in Alzheimer's disease. [PDF]
Int J Alzheimers Dis, 2014 The accumulation of beta-amyloid [Aβ] within senile plaques [SP] is characteristic of these lesions in Alzheimer's disease. The accumulation of Aβ 42, in particular, in the superior temporal [ST] cortex may result from an inability of the blood brain ...
Provias J, Jeynes B.
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A History of Senile Plaques: From Alzheimer to Amyloid Imaging. [PDF]
J Neuropathol Exp Neurol, 2022 Senile plaques have been studied in postmortem brains for more than 120 years and the resultant knowledge has not only helped us understand the etiology and pathogenesis of Alzheimer disease (AD), but has also pointed to possible modes of prevention and ...
Beach TG.
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Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques. [PDF]
Nat Neurosci, 2022 Autophagy is markedly impaired in Alzheimer’s disease (AD). Here we reveal unique autophagy dysregulation within neurons in five AD mouse models in vivo and identify its basis using a neuron-specific transgenic mRFP-eGFP-LC3 probe of autophagy and pH ...
Lee JH +16 more
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RTN1 and RTN3 protein are differentially associated with senile plaques in Alzheimer's brains. [PDF]
Sci Rep, 2017 Reticulon proteins (RTNs), consisting of RTN1 to RTN4, were previously shown to interact with BACE1 by negatively modulating its secretase activity. In RTN3-null mice, RTN1 expression was slightly elevated.
Shi Q, Ge Y, He W, Hu X, Yan R.
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The Pathogenesis of Senile Plaques [PDF]
Journal of Neuropathology and Experimental Neurology, 1997 Senile plaques (SP) are complicated lesions composed of diverse amyloid peptides and associated molecules, degenerating neuronal processes,a nd reactive glia. Evidence suggests that diffuse, neurocentric amyloid deposits evolve over time with formation of discrete niduses that eventually become neuritic SP.
D. Dickson
openaire +4 more sources
THERAPEUTIC EFFECTS OF THE TRANSPLANTATION OF VEGF OVEREXPRESSING BONE MARROW MESENCHYMAL STEM CELLS IN THE HIPPOCAMPUS OF MURINE MODEL OF ALZHEIMER’S DISEASE [PDF]
Frontiers in Aging Neuroscience, 2014 Alzheimer´s disease (AD) is clinically characterized by progressive memory loss, behavioural and learning dysfunction and cognitive deficits, such as alterations in social interactions.
Karina de Oliveira Garcia +7 more
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