Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum [PDF]
Frontiers in Neuroanatomy, 2017 Genetic variations in the vacuolar protein sorting 10 protein (Vps10p) family have been linked to Alzheimer’s disease (AD). Here we demonstrate deposition of fragments from the Vps10p member sortilin at senile plaques (SPs) in aged and AD human cerebrum.
Xia Hu +17 more
doaj +4 more sources
Enriched Environment Significantly Reduced Senile Plaques in a Transgenic Mice Model of Alzheimer’s Disease, Improving Memory [PDF]
Frontiers in Aging Neuroscience, 2018 Alzheimer’s disease (AD) is associated with a progressive dementia, and there is good evidence that it is more pronounced in individuals that have fewer stimuli during their lives.
Janaina Balthazar +5 more
doaj +2 more sources
THERAPEUTIC EFFECTS OF THE TRANSPLANTATION OF VEGF OVEREXPRESSING BONE MARROW MESENCHYMAL STEM CELLS IN THE HIPPOCAMPUS OF MURINE MODEL OF ALZHEIMER’S DISEASE [PDF]
Frontiers in Aging Neuroscience, 2014 Alzheimer´s disease (AD) is clinically characterized by progressive memory loss, behavioural and learning dysfunction and cognitive deficits, such as alterations in social interactions.
Karina de Oliveira Garcia +7 more
doaj +4 more sources
The Pathogenesis of Senile Plaques [PDF]
Journal of Neuropathology and Experimental Neurology, 1997 Senile plaques (SP) are complicated lesions composed of diverse amyloid peptides and associated molecules, degenerating neuronal processes,a nd reactive glia. Evidence suggests that diffuse, neurocentric amyloid deposits evolve over time with formation of discrete niduses that eventually become neuritic SP.
Dennis W. Dickson
openaire +3 more sources
Ceramides and sphingomyelinases in senile plaques
Neurobiology of Disease, 2014 The senile plaque is a hallmark lesion of Alzheimer disease (AD). We compared, without a priori, the lipidome of the senile plaques and of the adjacent plaque-free neuropil.
Maï Panchal +11 more
doaj +3 more sources
Origins of the Superiority of Oscillating Electric Fields for Disrupting Senile Plaques: Insights from the 7-Residue Fragment and the Full-length Aβ-42 Peptide. [PDF]
J Am Chem SocKalita S, Danovich D, Shaik S.
europepmc +2 more sources
Immune mechanism in senile plaque formation
Pathophysiology, 1994 Alzheimer disease (AD) is characterized by the appearance of two very different lesions, senile plaques and neurofibrillary tangles (NFTs). The pathological process which causes the disease must be responsible for both, but how they are linked is still a mystery.
Patrick L. McGeer +4 more
openaire +2 more sources
RTN1 and RTN3 protein are differentially associated with senile plaques in Alzheimer's brains. [PDF]
Sci Rep, 2017 Shi Q, Ge Y, He W, Hu X, Yan R.
europepmc +3 more sources
Pathological Proteins in Senile Plaques.
The Tohoku Journal of Experimental Medicine, 1994 The beta-amyloid protein deposits of Alzheimer disease, whether in diffuse or consoliated form, are an agglomeration of many extracellular proteins. At least 35 have been reported as components of senile plaques, most of which also occur in diffuse deposits. More than half of these proteins are directly associated with the immune system.
P L, McGeer +4 more
openaire +4 more sources
Synaptic Vesicle Glycoprotein 2A Suppresses Amyloidogenesis Beyond Its Synaptic Role: A Novel Mechanism Disrupting BACE1 Binding and Altering APP Localization. [PDF]
Aging CellSynaptic vesicle glycoprotein 2A, the newly identified APP‐binding protein, reduces amyloid‐β plaque deposition in Alzheimer's disease by suppressing the amyloidogenic pathway through inhibition of BACE1‐APP interaction and alteration of APP endosomal‐lysosomal localization.
Wang X +11 more
europepmc +2 more sources