Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease
Neurobiology of Disease, 2009 Senile plaque-associated changes in neuronal connectivity such as altered neurite trajectory, dystrophic swellings, and synapse and dendritic spine loss are thought to contribute to cognitive dysfunction in Alzheimer's disease and mouse models ...
Tara L. Spires-Jones +7 more
doaj +1 more source
Perusinis II. Fall: Der Alzheimer Patient R.M. Geschichte, Genealogie und Genetik eines psychiatriehistorischen Falls [PDF]
, 2012 1.American Journal of Alzheimer`s Disease and Other Dementias: 2010; 25:189-192 100th anniversary of PERUSINI`S SECOND CASE: PATIENT RM and his KINDRED
Braun, Birgit
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Nanoscopic Mapping of the Extracellular Space in Amyloid Plaque‐rich Cortex
Advanced Science, Volume 13, Issue 1, 5 January 2026.The extracellular space and diffusion around amyloid plaques are examined using shadow imaging and single‐particle tracking. Increased diffusivity is found near plaques, extracellular matrix alterations, and plaque core penetrability that varies with amyloid phenotype.
Juan Estaún‐Panzano +11 more
wiley +1 more source
Interpretable classification of Alzheimer's disease pathologies with a convolutional neural network pipeline. [PDF]
, 2018 Neuropathologists assess vast brain areas to identify diverse and subtly-differentiated morphologies. Standard semi-quantitative scoring approaches, however, are coarse-grained and lack precise neuroanatomic localization.
Beckett, Laurel +6 more
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Altered Expression of the CB1 Cannabinoid Receptor in the Triple Transgenic Mouse Model of Alzheimer's Disease [PDF]
, 2014 The endocannabinoid system has gained much attention as a new potential pharmacotherapeutic target in various neurodegenerative diseases, including Alzheimer's disease (AD).
*EQUAL CONTRIBUTION +12 more
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Brain‐peripheral proteome crosstalk in Alzheimer's disease with and without diabetes mellitus
Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.Abstract BACKGROUND Although considerable research has investigated diabetes mellitus (DM) as a risk factor for Alzheimer's disease (AD) dementia, the mechanistic understanding of the associations between peripheral and central biological processes in AD and AD within DM remains limited.
Anat Yaskolka Meir +10 more
wiley +1 more source
Rodent Aβ Modulates the Solubility and Distribution of Amyloid Deposits in Transgenic Mice [PDF]
, 2007 The amino acid sequence of amyloid precursor protein (APP) is highly conserved, and age-related Abeta aggregates have been described in a variety of vertebrate animals, with the notable exception of mice and rats.
Borchelt, David R. +7 more
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Bilateral senile scleral plaques mimicking post-inflammatory scleral ectasia
Indian Journal of Ophthalmology, 2004 Scleral plaque is a commonly occurring change in older individuals. We report a case of bilateral scleral plaques seen in an elderly female patient.
Murthy Somasheila, Sangwan Virender
doaj
Targeting neuroinflammation in Alzheimer’s disease [PDF]
, 2016 Almost 47 million people suffer from dementia worldwide, with an estimated new case diagnosed every 3.2 seconds. Alzheimer’s disease (AD) accounts for approximately 60%–80% of all dementia cases. Given this evidence, it is clear dementia represents one
Bronzuoli, MARIA ROSANNA +3 more
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The Alzheimer variant of Lewy body disease: A pathologically confirmed case-control study [PDF]
, 2005 The objective of the study was to identify clinical features that distinguish patients with dementia with Lewy bodies (DLB), who were classified as Alzheimer's disease ( AD) patients, from patients with AD.
Busch, R. +7 more
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