Results 101 to 110 of about 63,937 (247)

The role of butyrylcholinesterase in the pathogenesis of Alzheimer's disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2017
Alzheimer's disease (AD) is a neurodegenerative disease of unknown etiology and pathogenesis. The typical pathological changes of AD include neuritic plaques [NPs, senile plaques (SPs)] with deposition of β-amyloid protein (Aβ) and neurofibrillary ...
Hao WU, Xu-dong LI, Dan-tao PENG, Jin-song JIAO, Yan-feng LI, Pu-lin YU, Yong JI   +6 more
doaj  

Senile plaque calcification of the lamina circumvoluta medullaris in Alzheimer's disease

, 2021
R. Schober, Isabel Hilbrich, Carsten Jäger, Max Holzer   +3 more
openalex   +1 more source

Senile plaques and phosphorylated tau deposition in a super-aged rhesus monkey (Macaca mulatta). [PDF]

J Vet Med Sci, 2023
Iwaide S, Nakayama Y, Chambers JK, Uchida K, Nakagawa D, Yamanashi Y, Bando H, Murakami T.   +7 more
europepmc   +1 more source

Dogs with cognitive dysfunction syndrome: a natural model of Alzheimer's Disease [PDF]

, 2014
In the search for appropriate models for Alzheimer's disease (AD) involving animals other than rodents, several laboratories are working with animals that naturally develop cognitive dysfunction. Among the animals tested, dogs are quite unique in helping
Bosch, Maria Neus, Gimeno-Bayon, Javier, Mahy Gehenne, Josette Nicole, Pugliese, Marco, Rodríguez Allué, Manuel José   +4 more
core   +2 more sources

Microdose lithium improves behavioral deficits and modulates molecular mechanisms of memory formation in female SAMP-8, a mouse model of accelerated aging.

PLoS ONE
Alzheimer's disease (AD) is the most common neuronal disorder that leads to the development of dementia. Until nowadays, some therapies may alleviate the symptoms, but there is no pharmacological treatment. Microdosing lithium has been used to modify the
Arthur Antonio Ruiz Pereira, Alessandra Macedo Pinto, Helena Nascimento Malerba, Mariana Toricelli, Hudson Sousa Buck, Tania Araujo Viel   +5 more
doaj   +1 more source

Alternative neural circuitry that might be impaired in the development of Alzheimer disease

Frontiers in Neuroscience, 2015
It is well established that some individuals with normal cognitive capacity have abundant senile plaques in their brains. It has been proposed that those individuals are resilient or have compensation factors to prevent cognitive decline. In this comment,
Jesus eAvila, Jesus eAvila, George ePerry, Bryan Andrew Strange, Bryan Andrew Strange, Felix eHernandez, Felix eHernandez   +6 more
doaj   +1 more source

How Can Static and Oscillating Electric Fields Serve in Decomposing Alzheimer's and Other Senile Plaques? [PDF]

J Am Chem Soc, 2023
Kalita S, Bergman H, Dubey KD, Shaik S.
europepmc   +1 more source

Alzheimer disease and platelets: how’s that relevant

Immunity & Ageing, 2012
Alzheimer Disease (AD) is the most common neurodegenerative disorder worldwide, and account for 60% to 70% of all cases of progressive cognitive impairment in elderly patients.
Catricala Silvia, Torti Mauro, Ricevuti Giovanni   +2 more
doaj   +1 more source

Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575

Molecular Neurodegeneration, 2009
The γ-secretase complex is a major therapeutic target for the prevention and treatment of Alzheimer's disease. Previous studies have shown that treatment of young APP mice with specific inhibitors of γ-secretase prevented formation of new plaques. It has
Golde Todd E, Das Pritam, Fauq Abdul, Borrelli Laura A, Thyssen Diana, Subramanian Meenakshi, Garcia-Alloza Monica, Hyman Bradley T, Bacskai Brian J   +8 more
doaj   +1 more source

Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques. [PDF]

Nat Neurosci, 2022
Lee JH, Yang DS, Goulbourne CN, Im E, Stavrides P, Pensalfini A, Chan H, Bouchet-Marquis C, Bleiwas C, Berg MJ, Huo C, Peddy J, Pawlik M, Levy E, Rao M, Staufenbiel M, Nixon RA.   +16 more
europepmc   +1 more source