Results 111 to 120 of about 365,500 (282)
Bilateral senile scleral plaques mimicking post-inflammatory scleral ectasia
Indian Journal of Ophthalmology, 2004 Scleral plaque is a commonly occurring change in older individuals. We report a case of bilateral scleral plaques seen in an elderly female patient.
Murthy Somasheila, Sangwan Virender
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Alzheimer's &Dementia, Volume 21, Issue 8, August 2025.Abstract INTRODUCTION Alzheimer's disease (AD) is a leading cause of dementia, with vascular dysfunction being an early pathogenic event. Cardiovascular interventions show therapeutic promise, hence may improve neurovascular coupling (NVC) and resting‐state functional connectivity (RSFC) hemodynamic responses.
Aline R. Zimmer +3 more
wiley +1 more source
The role of butyrylcholinesterase in the pathogenesis of Alzheimer's disease
Chinese Journal of Contemporary Neurology and Neurosurgery, 2017 Alzheimer's disease (AD) is a neurodegenerative disease of unknown etiology and pathogenesis. The typical pathological changes of AD include neuritic plaques [NPs, senile plaques (SPs)] with deposition of β-amyloid protein (Aβ) and neurofibrillary ...
Hao WU +6 more
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Dogs with cognitive dysfunction syndrome: a natural model of Alzheimer's Disease [PDF]
, 2014 In the search for appropriate models for Alzheimer's disease (AD) involving animals other than rodents, several laboratories are working with animals that naturally develop cognitive dysfunction. Among the animals tested, dogs are quite unique in helping
Bosch, Maria Neus +4 more
core +2 more sources
Endothelial LRP1 transports amyloid-β1-42 across the blood-brain barrier [PDF]
, 2016 According to the neurovascular hypothesis, impairment of low-density lipoprotein receptor-related protein-1 (LRP1) in brain capillaries of the blood-brain barrier (BBB) contributes to neurotoxic amyloid-beta (A beta) brain accumulation and drives ...
Alessandro Di Spiezio +34 more
core +2 more sources
Alzheimer's &Dementia, Volume 21, Issue 8, August 2025.Abstract Diabetic retinopathy (DR) and Alzheimer's disease (AD) are progressive neurodegenerative disorders affecting the eye and the brain, respectively. Despite targeting different organs, they share common molecular mechanisms. A central process connecting these conditions is the unfolded protein response (UPR), which maintains protein homeostasis ...
Adrián G. Palacios +2 more
wiley +1 more source
Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and Apoptosis in Alzheimer’s Disease
Journal of Pharmacological Sciences, 2005 Alzheimer’s disease (AD) is the most common neurodegenerative disorder of late life characterized by insidious, chronic, and progressive memory impairment in association with the accumulation of senile plaques, neurofibrillary tangles, and massive loss ...
Kazuhiro Takuma +3 more
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Senile plaques and phosphorylated tau deposition in a super-aged rhesus monkey (Macaca mulatta). [PDF]
J Vet Med Sci, 2023 Iwaide S +7 more
europepmc +1 more source
Glia, Volume 73, Issue 8, Page 1727-1745, August 2025.Main Points In a pre‐symptomatic mouse model of Alzheimer disease, despite higher amyloid‐β load females display less plaques than males. More efficient synaptic transmission as well as less microgliosis point to better early coping with pathogenesis in females.
Thomas Chaigneau +7 more
wiley +1 more source
PLoS ONEAlzheimer's disease (AD) is the most common neuronal disorder that leads to the development of dementia. Until nowadays, some therapies may alleviate the symptoms, but there is no pharmacological treatment. Microdosing lithium has been used to modify the
Arthur Antonio Ruiz Pereira +5 more
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