Results 121 to 130 of about 63,937 (247)

Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice. [PDF]

, 2019
BackgroundAlzheimer disease (AD) is characterized by the accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau, which together lead to neurodegeneration and cognitive decline.
Agadjanyan, Michael G, Antonyan, Tatevik, Blurton-Jones, Mathew, Chailyan, Gor, Coburn, Morgan A, Cribbs, David H, Danhash, Emma, Davtyan, Hayk, Ghochikyan, Anahit, Hovakimyan, Armine, Kiani Shabestari, Sepideh, Petrovsky, Nikolai, Petrushina, Irina, Svystun, Olga, Zagorski, Karen   +14 more
core  

Mostly Separate Distributions of CLAC- versus Aβ40- or Thioflavin S-Reactivities in Senile Plaques Reveal Two Distinct Subpopulations of β-Amyloid Deposits [PDF]

, 2004
Hisatomo Kowa, Tomoko Sakakura, Yusuke Matsuura, Tomoko Wakabayashi, David M. A. Mann, Karen Duff, Shoji Tsuji, Tadafumi Hashimoto, Takeshi Iwatsubo   +8 more
openalex   +1 more source

Ultrastructural studies in APP/PS1 mice expressing human ApoE isoforms: implications for Alzheimer’s disease [PDF]

, 2012
Alzheimer’s disease is characterized in part by extracellular aggregation of the amyloid-β peptide in the form of diffuse and fibrillar plaques in the brain. Electron microscopy (EM) has made an important contribution in understanding of the structure of
Dirkranian, Krikor, Holtzman, David M, Kim, Jungsu, Levy, Marilyn A, Stewart, Floy R   +4 more
core   +2 more sources

Cerebrovascular Smooth Muscle Actin Is Increased in Nondemented Subjects With Frequent Senile Plaques at Autopsy: Implications for the Pathogenesis of Alzheimer Disease [PDF]

, 2009
Christine M. Hulette, John F. Ervin, Yvette Edmonds, Samantha Antoine, Nicolas A. Stewart, Mari H. Szymanski, Kathleen M. Hayden, Carl F. Pieper, James R. Burke, Kathleen A. Welsh‐Bohmer   +9 more
openalex   +1 more source

Neurobiological pathways to Alzheimer's disease: Amyloid-beta, TAU protein or both?

Dementia & Neuropsychologia
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline, including memory loss, behavioral and psychological symptoms and personality changes.
Vanessa de Jesus R. de Paula, Fabiana Meira Guimarães, Breno Satler Diniz, Orestes Vicente Forlenza   +3 more
doaj   +1 more source

Early Diagnosis of Alzheimer's disease by NIRF Spectroscopy and Nuclear Medicine [PDF]

, 2011
There is an urgent need for the early detection of diseases such as Alzheimer’s (AD) and Cancers in order to enable their successful treatment. Cancer is the second major cause of death after Heart Disease, and AD is the third major cause of death
I. C. Baianu
core   +1 more source

Does amyloid precede paired helical filaments in the senile plaque? A study of 15 cases with graded intellectual status in aging and Alzheimer disease [PDF]

, 1988
Charles Duyckaerts, P. Delaère, V. Poulain, Jean‐Pierre Brion, J J Hauw   +4 more
openalex   +1 more source

Compensatory responses induced by oxidative stress in Alzheimer disease

Biological Research, 2006
Oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques.
PAULA I MOREIRA, XIONGWEI ZHU, QUAN LIU, KAZUHIRO HONDA, SANDRA L SIEDLAK, PEGGY L HARRIS, MARK A. SMITH, GEORGE PERRY   +7 more
doaj  

In Situ Labeling of Dying Cortical Neurons in Normal Aging and in Alzheimer's Disease: Correlations with Senile Plaques and Disease Progression [PDF]

, 1996
Juan C. Troncoso, Renat Sukhov, Claudia H. Kawas, Vassilis E. Koliatsos   +3 more
openalex   +1 more source

Senile scleral plaque – Clinical and anterior segment optical coherence tomography correlation

, 2023
Rama Rajagopal, Maria T Priyanka, Janarthanam Jothi Balaji   +2 more
openalex   +1 more source