How Can Static and Oscillating Electric Fields Serve in Decomposing Alzheimer's and Other Senile Plaques? [PDF]
J Am Chem Soc, 2023 Kalita S, Bergman H, Dubey KD, Shaik S.
europepmc +1 more source
The role of the Amyloid Precursor Protein mutations and PERK-dependent signaling pathways in the pathogenesis of Alzheimer’s disease [PDF]
, 2016 Alzheimer’s disease (AD) is a highly complex, progressive, age-related neurodegenerative human disease entity. The genetic basis of AD is strictly connected with occurrence of mutations in Amyloid Precursor (APP) gene on chromosome 21.
Diehl, J. Alan +5 more
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International Journal of Geriatric Psychiatry, Volume 40, Issue 8, August 2025.ABSTRACT Objective To investigate the dose‐response relationship between handgrip strength and incidence of Alzheimer's disease (AD) in middle‐aged and older adults. Design Longitudinal study. Patients and Methods A longitudinal study was conducted in people over 50 years old in 27 European countries and Israel.
Rodrigo Núñez‐Cortés +6 more
wiley +1 more source
Neurobiology of Disease, 2021 Alzheimer’s disease (AD) is the most common dementia worldwide and is characterized by the presence of senile plaques by amyloid-beta (Aβ) and neurofibrillary tangles of hyperphosphorylated Tau protein.
Michele Longoni Calió +6 more
doaj
Chondroitin Sulfate Proteoglycans Are Associated with the Lesions of Alzheimer\u27s Disease [PDF]
, 1993 Chondroitin sulfate proteoglycans (CSPG) are extracellular matrix proteins inhibitory to neurite outgrowth in vitro and correlated with decreased neurite outgrowth after CNS injury.
Canning, David R. +3 more
core
S100B inhibitor pentamidine attenuates reactive gliosis and reduces neuronal loss in a mouse model of Alzheimer's disease [PDF]
, 2015 Among the different signaling molecules released during reactive gliosis occurring in Alzheimer’s disease (AD), the astrocytederived S100B protein plays a key role in neuroinflammation, one of the hallmarks of the disease.
Capoccia, Elena +6 more
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Critical Review: THE NATURE AND SIGNIFICANCE OF SENILE PLAQUES. [PDF]
, 1929 M. Critchley
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Astrocyte in Neurological Disease: Pathogenesis and Therapy
MedComm, Volume 6, Issue 8, August 2025.This review provides comprehensive overview of astrocytes in neurological disorders. Astrocytes contribute to neurological disorders via A1/A2 polarization, inducing neuroinflammation, synaptic, and BBB dysfunction. Metabolic disturbances in glucose, lipid, and amino acid pathways leading to oxidative stress and mitochondrial damage.
Meihui Huang +4 more
wiley +1 more source
Alternative neural circuitry that might be impaired in the development of Alzheimer disease
Frontiers in Neuroscience, 2015 It is well established that some individuals with normal cognitive capacity have abundant senile plaques in their brains. It has been proposed that those individuals are resilient or have compensation factors to prevent cognitive decline. In this comment,
Jesus eAvila +6 more
doaj +1 more source
The Progression of β-amyloid Deposition in the Frontal Cortex of the Aged Canine [PDF]
, 1997 Brains from 41 aged canines (≥10 years of age) were examined immunohistochemically to characterize the laminar distribution and age-related progression of β-amyloid (Aβ) in frontal cortex. We classified the Aβ patterns into four distinct types.
Cotman, Carl W. +9 more
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