Results 131 to 140 of about 365,500 (282)

Isolated senile plaque cores in Alzheimer's disease and Down's syndrome show differences in morphology. [PDF]

, 1986
David Allsop, M.T. Kidd, Michael Landon, A. H. Tomlinson   +3 more
openalex   +1 more source

Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 8, Page 1314-1329, August 2025.
Abstract Before the controversial approval of humanized monoclonal antibody lecanemab, which binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for Alzheimer's disease (AD) were symptomatic. The researchers are still struggling to find a breakthrough in AD therapeutic medicine, which is partially attributable to lack in ...
Sharif Arar, Md Anzarul Haque, Rakez Kayed   +2 more
wiley   +1 more source

Alois alzheimer

Archives of Mental Health, 2015
Background: Alois Alzheimer is a Bavarian born German psychiatrist who is considered as the “Father of Neuropathology” was the first to describe the main neuro pathologic characteristics of the peculiar disease in the brain of a woman showing progressive
Padmapriya Gorjilli
doaj  

Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575

Molecular Neurodegeneration, 2009
The γ-secretase complex is a major therapeutic target for the prevention and treatment of Alzheimer's disease. Previous studies have shown that treatment of young APP mice with specific inhibitors of γ-secretase prevented formation of new plaques. It has
Golde Todd E, Das Pritam, Fauq Abdul, Borrelli Laura A, Thyssen Diana, Subramanian Meenakshi, Garcia-Alloza Monica, Hyman Bradley T, Bacskai Brian J   +8 more
doaj   +1 more source

Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice. [PDF]

, 2019
BackgroundAlzheimer disease (AD) is characterized by the accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau, which together lead to neurodegeneration and cognitive decline.
Agadjanyan, Michael G, Antonyan, Tatevik, Blurton-Jones, Mathew, Chailyan, Gor, Coburn, Morgan A, Cribbs, David H, Danhash, Emma, Davtyan, Hayk, Ghochikyan, Anahit, Hovakimyan, Armine, Kiani Shabestari, Sepideh, Petrovsky, Nikolai, Petrushina, Irina, Svystun, Olga, Zagorski, Karen   +14 more
core  

ATHEROSCLEROTIC CHANGES OF BRACHIOCEPHALIC ARTERIES IN DIFFERENT AGE GROUPS ACCORDING TO SONOGRAPHY

Siberian Journal of Life Sciences and Agriculture
Background. One of the most frequent causes of death is considered to be stroke on the back of atherosclerosis of the extracranial carotid arteries. Detection of atherosclerosis at an early stage facilitates timely prevention and reduces the risk of ...
Anna P. Boreyko, Taisiya D. Kulakova, Svetlana F. Lukina   +2 more
doaj   +1 more source

Alzheimer disease and platelets: how’s that relevant

Immunity & Ageing, 2012
Alzheimer Disease (AD) is the most common neurodegenerative disorder worldwide, and account for 60% to 70% of all cases of progressive cognitive impairment in elderly patients.
Catricala Silvia, Torti Mauro, Ricevuti Giovanni   +2 more
doaj   +1 more source

Augmented Senile Plaque Load in Aged Female β-Amyloid Precursor Protein-Transgenic Mice [PDF]

, 2001
Michael J. Callahan, William J. Lipinski, Feng Bian, Robert A. Durham, Amy Pack, Lary C. Walker   +5 more
openalex   +1 more source

Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer’s Disease: Tangle Formation, Amyloid-β, and Microglia in Alzheimer’s Disease

Journal of Pharmacological Sciences, 2012
Pathological hallmarks of Alzheimer’s disease (AD) include senile plaques, neurofibrillary tangles (NFTs), synaptic loss, and neurodegeneration. Senile plaques are composed of amyloid-β (Aβ) and are surrounded by microglia, a primary immune effector cell
Kazuyuki Takata, Yoshihisa Kitamura
doaj  

The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease

Journal of Neuroinflammation, 2006
Alzheimer's disease is the most common cause of dementia in the elderly, and manifests as progressive cognitive decline and profound neuronal loss.
Landreth Gary E, Wilkinson Brandy L
doaj   +1 more source