Results 241 to 250 of about 365,500 (282)

Aluminosilicates and senile plaque formation in Alzheimerʼs disease

Alzheimer Disease & Associated Disorders, 1986
Aluminium and silicon were found to be colocalised in the central region of senile plaque cores in studies with energy dispersive X-ray microanalysis. The distribution of these elements was similar in cores isolated from the cerebral cortex of patients with senile dementia of the Alzheimer type and in cores studied in situ from tissue sections from the
Candy JM, Oakley AE, Klinowski J, Carpenter TA, Perry RH, Atack JR, Perry EK, Blessed G, Fairbairn A, Edwardson JA   +9 more
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SENILE HYALINE SCLERAL PLAQUES

Archives of Ophthalmology, 1946
To the Editor: —Dr. Kenneth L. Roper's paper entitled "Senile Hyaline Scleral Plaques" (Arch. Ophth. 34: 283 [Oct.] 1945) has enhanced the meager knowledge of diseases of the sclera. Unfortunately, in his section on differential diagnosis no mention is made of ochronosis. I observed a 78 year old man with bilateral "mesial" plaques while preparing my
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HISTOGENESIS OF SENILE PLAQUES

Archives of Neurology And Psychiatry, 1941
The first reference in the literature to the existence of senile plaques was made as early as 1892,1but the origin and development of such plaques are still a matter of controversy. No less than twenty different concepts regarding their origin have appeared in the literature.
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The relationship between senile plaques and cerebral blood vessels in Alzheimer’s disease and senile dementia

Virchows Archiv B Cell Pathology Including Molecular Pathology, 1982
Several kinds of senile plaque found in 6 brains (4 from patients with Alzheimer's disease and 2 from patients with senile dementia) were examined in serial sections by light electron microscopy. The results obtained were as follows. All the senile plaques contained at least some amyloid fibrils, and these seemed to be produced at the basement ...
Taihei Miyakawa, Yasushi Higuchi, Akitomo Shimoji, Ryoko Kuramoto   +3 more
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Laminar distribution of neocortical senile plaques in senile dementia of the alzheimer type

Acta Neuropathologica, 1986
A prospective longitudinal study was undertaken in a geriatric hospital on women over 75 years of age, clinically diagnosed as either intellectually normal or having senile dementia of the Alzheimer type (SDAT) of varying degrees of severity. Mental impairment was assessed prospectively.
F. Bastenaire, P. Berthaux, C. Poulain, François Piette, V. Rainsard, J. J. Hauw, Charles Duyckaerts, F. Javoy-Agid   +7 more
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Senile plaques in cortex of aged normal monkeys

Brain Research, 1985
The density, type, and distributions of cortical senile plaques were determined in 6 aged rhesus monkeys. Plaque densities were highest in prefrontal and temporal cortices and lowest in occipital cortex. Neurite plaques contained many argentophilic neurites and little amyloid, mixed plaques had both neurites and amyloid, and amyloid plaques showed ...
R G, Struble, D L, Price, L C, Cork, D L, Price   +3 more
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Acetylcholinesterase activity in senile plaques of aged macaques

Neurobiology of Aging, 1984
A modified acetylcholinesterase (AChE)-histochemical technique, which demonstrates axonal morphology to a high degree, was used to examine the neocortices of aged monkeys. This approach disclosed slender linear axonal profiles in young animals. In older monkeys, there was a variety of abnormalities of AChE-containing fibers, including multifocal ...
Donald L. Price, Linda C. Cork, Robert G. Struble, John C. Hedreen   +3 more
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Classification of Senile Plaques by Three‐Dimensional Analysis

Psychiatry and Clinical Neurosciences, 1993
Abstract: We evaluated the number of each senile plaque subtype in Alzheimer's brain by the usual two‐dimensional analysis using a single, methenamine silver stained section and three‐dimensional analysis using serial section reconstruction. The number of classic plaques was underestimated due to a lack of precision in the usual evaluating procedures (
Hiroyuki Yoshida, Taihei Miyakawa, Takemi Kimura, Toshiyuki Hisano, Keishi Ueda   +4 more
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Histochemical similarity of senile plaque amyloid to apudamyloid

Virchows Archiv A Pathological Anatomy and Histology, 1977
Senile plaque amyloid of both isolated and perivascular (dyshoric) types was compared histochemically to other major types of amyloid. In contrast to most amyloids tested, senile plaque amyloid contained less tryptophan and tyrosine reactivity and more alcianophilia.
James M. Powers, Samuel S. Spicer
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THE ORIGIN AND FORMATION OF SENILE PLAQUES

Archives of Neurology And Psychiatry, 1931
Senile plaques were first described in 1892 by Blocq and Marinesco, 1 who called them sclerotic plaques of neuroglia, a name which was later changed by Redlich 2 to miliary sclerosis. The term senile plaque was first applied to the lesion by Simchowicz. 3 Since the first description of Blocq and Marinesco, numerous authors have tried to establish the
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