Results 21 to 30 of about 63,937 (247)
Journal of Lipid Research, 2010 Extensive knowledge of the protein components of the senile plaques, one of the hallmark lesions of Alzheimer’s disease, has been acquired over the years, but their lipid composition remains poorly known. Evidence suggests that cholesterol contributes to
Maï Panchal +6 more
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Research in Pharmaceutical Sciences, 2020 Background and purpose: Venenum Bufonis is a Chinese traditional medicine produced from the glandular secretions of toads that contain biogenic amines, which have anti-inflammatory properties. The present study aimed to examine the effect of Bufo viridis
Shima Shirzad +3 more
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Ex vivo analysis platforms for monitoring amyloid precursor protein cleavage
Frontiers in Molecular Neuroscience, 2023 Alzheimer’s disease (AD) is a progressive neurodegenerative brain disorder and the most common cause of dementia in the elderly. The presence of large numbers of senile plaques, neurofibrillary tangles, and cerebral atrophy is the characteristic feature ...
Yuji Kamikubo +6 more
doaj +1 more source
Dense-core senile plaques in the Flemish variant of Alzheimer's disease are vasocentric [PDF]
, 2002 Alzheimer's disease (AD) is characterized by deposition of beta-amyloid (Abeta) in diffuse and senile plaques, and variably in vessels. Mutations in the Abeta-encoding region of the amyloid precursor protein (APP) gene are frequently associated with very
Broeckhoven, C. (Christine) van +13 more
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Empagliflozin reduces vascular damage and cognitive impairment in a mixed murine model of Alzheimer's disease and type 2 diabetes [PDF]
, 2020 Background Both Alzheimer's disease (AD) and type 2 diabetes (T2D) share common pathological features including inflammation, insulin signaling alterations, or vascular damage.
Alves-Martinez, Pilar +8 more
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Frontiers in Cellular Neuroscience, 2019 Alzheimer disease is a neurodegenerative disease characterized by the presence of senile plaques composed of amyloid-β (Aβ) peptide, neurofibrillary tangles, neuronal loss and neuroinflammation.
Carlos Martínez-Frailes +13 more
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Parenchymal and vascular Aβ-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease [PDF]
, 2008 The deposition of the amyloid β-protein (Aβ) is one of the pathological hallmarks of Alzheimer's disease (AD). Aβ-deposits show the morphology of senile plaques and cerebral amyloid angiopathy (CAA). Senile plaques and vascular Aβ-deposits occur first in
Braak, Heiko +2 more
core +1 more source
A preclinical assessment of neural stem cells as delivery vehicles for anti-amyloid therapeutics. [PDF]
PLoS ONE, 2012 Transplantation of neural stems cells (NSCs) could be a useful means to deliver biologic therapeutics for late-stage Alzheimer's disease (AD). In this study, we conducted a small preclinical investigation of whether NSCs could be modified to express ...
eMalick G Njie +9 more
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Alzheimer and vascular brain disease: Senile dementia. [PDF]
, 2015 Alois Alzheimer is best known for his description of a novel disease, subsequently named after him. However, his wide range of interests also included vascular brain diseases.
Engelhardt, Eliasz, Grinberg, Lea T
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Glial Cell Extracellular Matrix in Alzheimer’s Disease [PDF]
, 1995 Many studies have yielded conflicting results regarding the toxicity of AB, the peptide which is the principal component of senile plaques in brains of patients with Alzheimer\u27s disease.
Canning, David R. +2 more
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