Results 31 to 40 of about 63,937 (247)
The Response of Cerebral Cortex to Haemorrhagic Damage: Experimental Evidence from a Penetrating Injury Model [PDF]
, 2015 Understanding the response of the brain to haemorrhagic damage is important in haemorrhagic stroke and increasingly in the understanding the cerebral degeneration and dementia that follow head trauma and head-impact sports.
Johnstone, Daniel M. +4 more
core +1 more source
NADPH oxidase as a therapeutic target in Alzheimer\u27s disease [PDF]
, 2008 At present, available treatments for Alzheimer\u27s disease (AD) are largely unable to halt disease progression. Microglia, the resident macrophages in the brain, are strongly implicated in the pathology and progressively degenerative nature of AD ...
Block, Michelle L
core +4 more sources
Membrane biophysics and mechanics in Alzheimer's disease [PDF]
, 2010 Alzheimer's disease is a chronic neurodegenerative disorder characterized by neuronal loss, cerebrovascular inflammation, and accumulation of senile plaques in the brain parenchyma and cerebral blood vessels. Amyloid-β peptide (Aβ), a major component
Askarova, Sholpan +2 more
core +1 more source
What is the molecular pathology that underlies hippocampal memory decline? [PDF]
, 2009 Peer ...
Harrington, Charles R.
core +1 more source
Frontiers in Chemistry, 2021 Protein misfolding occurs due to the loss of native protein structure and adopts an abnormal structure, wherein the misfolded proteins accumulate and form aggregates, which result in the formation of amyloid fibrils that are associated with ...
E. Srinivasan +8 more
doaj +1 more source
Lipofuscin Hypothesis of Alzheimer’s Disease
Dementia and Geriatric Cognitive Disorders Extra, 2011 The primary culprit responsible for Alzheimer’s disease (AD) remains unknown. Aβ protein has been identified as the main component of amyloid of senile plaques, the hallmark lesion of AD, but it is not definitively established whether the formation of ...
Giorgio Giaccone +3 more
doaj +1 more source
HEWL interacts with dissipated oleic acid micelles, and decreases oleic acid cytotoxicity.
PLoS ONE, 2019 Senile plaques are well-known hallmarks of Alzheimer's Diseases (AD). However, drugs targeting tangles of the protein tau and plaques of β-amyloid have no significant effect on disease progression, and the studies on the underlying mechanism of AD remain
Qin Huang +5 more
doaj +1 more source
IBRO Reports, 2018 Hormesis is a dose response phenomenon of cells and organisms to various types of stressors. Mild stress stimulates prosurvival pathways and makes the cells adaptive to stressful conditions.
Narayan R. Mane +2 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Alzheimer’s disease (AD) is tightly related to endoplasmic reticulum stress (ER stress), which aggravates two dominant pathological manifestations of AD: senile plaques and neurofibrillary tangles. Berberine is widely applied in the clinical treatment of
Yue Wu +6 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2020 Amyloid-β (Aβ) peptides can form protease-resistant aggregates within and outside of neurons. Accumulation of these aggregates is a hallmark of Alzheimer’s disease (AD) neuropathology and contributes to devastating cognitive deficits associated with this
Bhanu Chandra Karisetty +5 more
doaj +1 more source