Results 31 to 40 of about 365,500 (282)
The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]
, 2015 Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S. +3 more
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Research in Pharmaceutical Sciences, 2020 Background and purpose: Venenum Bufonis is a Chinese traditional medicine produced from the glandular secretions of toads that contain biogenic amines, which have anti-inflammatory properties. The present study aimed to examine the effect of Bufo viridis
Shima Shirzad +3 more
doaj +1 more source
Alzheimer and vascular brain disease: Senile dementia. [PDF]
, 2015 Alois Alzheimer is best known for his description of a novel disease, subsequently named after him. However, his wide range of interests also included vascular brain diseases.
Engelhardt, Eliasz, Grinberg, Lea T
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Frontiers in Cellular Neuroscience, 2019 Alzheimer disease is a neurodegenerative disease characterized by the presence of senile plaques composed of amyloid-β (Aβ) peptide, neurofibrillary tangles, neuronal loss and neuroinflammation.
Carlos Martínez-Frailes +13 more
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Ex vivo analysis platforms for monitoring amyloid precursor protein cleavage
Frontiers in Molecular Neuroscience, 2023 Alzheimer’s disease (AD) is a progressive neurodegenerative brain disorder and the most common cause of dementia in the elderly. The presence of large numbers of senile plaques, neurofibrillary tangles, and cerebral atrophy is the characteristic feature ...
Yuji Kamikubo +6 more
doaj +1 more source
A preclinical assessment of neural stem cells as delivery vehicles for anti-amyloid therapeutics. [PDF]
PLoS ONE, 2012 Transplantation of neural stems cells (NSCs) could be a useful means to deliver biologic therapeutics for late-stage Alzheimer's disease (AD). In this study, we conducted a small preclinical investigation of whether NSCs could be modified to express ...
eMalick G Njie +9 more
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NADPH oxidase as a therapeutic target in Alzheimer\u27s disease [PDF]
, 2008 At present, available treatments for Alzheimer\u27s disease (AD) are largely unable to halt disease progression. Microglia, the resident macrophages in the brain, are strongly implicated in the pathology and progressively degenerative nature of AD ...
Block, Michelle L
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Senile scleral plaques and senile scleromalacia. [PDF]
British Journal of Ophthalmology, 1978 A case of senile scleral plaques is reported in which expulsion of a calcified plaque anterior to the insertion of the medial horizontal rectus muscle gave rise to senile scleromalacia. Histopathological examination revealed a second calcified plaque at the site of the contralateral senile scleral plaque in this eye.
openaire +3 more sources
Parenchymal and vascular Aβ-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease [PDF]
, 2008 The deposition of the amyloid β-protein (Aβ) is one of the pathological hallmarks of Alzheimer's disease (AD). Aβ-deposits show the morphology of senile plaques and cerebral amyloid angiopathy (CAA). Senile plaques and vascular Aβ-deposits occur first in
Braak, Heiko +2 more
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Pathological Proteins in Senile Plaques.
The Tohoku Journal of Experimental Medicine, 1994 The beta-amyloid protein deposits of Alzheimer disease, whether in diffuse or consoliated form, are an agglomeration of many extracellular proteins. At least 35 have been reported as components of senile plaques, most of which also occur in diffuse deposits. More than half of these proteins are directly associated with the immune system.
Osamu Yasuhara +4 more
openaire +3 more sources