Results 41 to 50 of about 63,937 (247)

Amyloid beta and diabetic pathology cooperatively stimulate cytokine expression in an Alzheimer's mouse model [PDF]

, 2020
Background Diabetes is a risk factor for developing Alzheimer's disease (AD); however, the mechanism by which diabetes can promote AD pathology remains unknown.
Fernández Ponce, Cecilia Matilde, García Alloza, Mónica, Hierro-Bujalance, Carmen, Infante-Garcia, Carmen, Ramos-Rodríguez, Juan José, Sankar, Sitara B., Weinstock, Laura D., Wood, Levi B.   +7 more
core   +3 more sources

Alterações encontradas em cérebros de indivíduos acima dos 65 anos e sua correlação com demência de Alzheimer Changes found in the brain of people over 65 years old and their correlation with Alzheimer disease

Arquivos de Neuro-Psiquiatria, 1997
Foram estudadas 12 amostras de cérebros de indivíduos acima de 65 anos. Estas amostras foram submetidas a três técnicas com o objetivo de se detectar placas senis ricas em β-amilóide: imuno-histoquímica para β-amilóide; técnica de Glees ...
Liana Lisboa Fernandez, Lígia M. Barbosa-Coutinho   +1 more
doaj   +1 more source

Probable Reasons for Neuron Copper Deficiency in the Brain of Patients with Alzheimer’s Disease: The Complex Role of Amyloid

Inorganics, 2022
Alzheimer’s disease is a progressive neurodegenerative disorder that eventually leads the affected patients to die. The appearance of senile plaques in the brains of Alzheimer’s patients is known as a main symptom of this disease.
Soghra Bagheri, Ali A. Saboury, Thomas Haertlé, Mauro Rongioletti, Luciano Saso   +4 more
doaj   +1 more source

APP processing in Alzheimer's disease

Molecular Brain, 2011
An important pathological feature of Alzheimer's disease (AD) is the presence of extracellular senile plaques in the brain. Senile plaques are composed of aggregations of small peptides called β-amyloid (Aβ).
Zhang Yun-wu, Thompson Robert, Zhang Han, Xu Huaxi   +3 more
doaj   +1 more source

Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and Apoptosis in Alzheimer’s Disease

Journal of Pharmacological Sciences, 2005
Alzheimer’s disease (AD) is the most common neurodegenerative disorder of late life characterized by insidious, chronic, and progressive memory impairment in association with the accumulation of senile plaques, neurofibrillary tangles, and massive loss ...
Kazuhiro Takuma, Shirley ShiDu Yan, David M. Stern, Kiyofumi Yamada   +3 more
doaj   +1 more source

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies [PDF]

, 2016
Acknowledgments This work was supported by The Croatian Science Foundation grant No. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Babić Leko, Mirjana, Bažadona, Danira, Buée, Luc, de Silva, Rohan, Delalle, Ivana, Giovanni, Giuseppe Di, Harrington, Charles, Hof, Patrick R., Jovanov-Milošević, Nataša, Wischik, Claude, Wray, Selina, Šimić, Goran   +11 more
core   +3 more sources

Leptin enhances adult neurogenesis and reduces pathological features in a transgenic mouse model of Alzheimer’s disease

Neurobiology of Disease, 2021
Alzheimer’s disease (AD) is the most common dementia worldwide and is characterized by the presence of senile plaques by amyloid-beta (Aβ) and neurofibrillary tangles of hyperphosphorylated Tau protein.
Michele Longoni Calió, Amanda Cristina Mosini, Darci Souza Marinho, Geisa Nogueira Salles, Fernando Henrique Massinhani, Gui Mi Ko, Marimélia Aparecida Porcionatto   +6 more
doaj   +1 more source

Senile scleral plaques and senile scleromalacia. [PDF]

British Journal of Ophthalmology, 1978
A case of senile scleral plaques is reported in which expulsion of a calcified plaque anterior to the insertion of the medial horizontal rectus muscle gave rise to senile scleromalacia. Histopathological examination revealed a second calcified plaque at the site of the contralateral senile scleral plaque in this eye.
openaire   +2 more sources

Monoaminergic Neuropathology in Alzheimer's disease [PDF]

, 2016
Acknowledgments This work was supported by The Croatian Science Foundation grant. no. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Bažadona, Danira, Buée, Luc, Delalle, Ivana, Giovanni, Giuseppe Di, Harrington, Charles R., Hof, Patrick R., Jovanov-Milošević, Nataša, Leko, Mirjana Babić, Silva, Rohan de, Wischik, Claude M., Wray, Selina, Šimić, Goran   +11 more
core   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source