Results 51 to 60 of about 365,500 (282)

Alterações encontradas em cérebros de indivíduos acima dos 65 anos e sua correlação com demência de Alzheimer Changes found in the brain of people over 65 years old and their correlation with Alzheimer disease

Arquivos de Neuro-Psiquiatria, 1997
Foram estudadas 12 amostras de cérebros de indivíduos acima de 65 anos. Estas amostras foram submetidas a três técnicas com o objetivo de se detectar placas senis ricas em β-amilóide: imuno-histoquímica para β-amilóide; técnica de Glees ...
Liana Lisboa Fernandez, Lígia M. Barbosa-Coutinho   +1 more
doaj   +1 more source

Integrating neuroinflammation biomarkers into the ATN(X) framework: Advances in Alzheimer's pathogenesis, diagnosis, and insights from non‐human primate models [PDF]

Alzheimers Dement
Abstract The amyloid/tau/neurodegeneration (ATN) biomarker framework has greatly progressed the diagnosis and staging of Alzheimer's disease (AD). However, recent research highlights neuroinflammation as an equally critical factor in AD pathology across humans, rodents, and non‐human primates (NHPs).
Jin Z, Lu Y, Tang H, Cui H.
europepmc   +2 more sources

Probable Reasons for Neuron Copper Deficiency in the Brain of Patients with Alzheimer’s Disease: The Complex Role of Amyloid

Inorganics, 2022
Alzheimer’s disease is a progressive neurodegenerative disorder that eventually leads the affected patients to die. The appearance of senile plaques in the brains of Alzheimer’s patients is known as a main symptom of this disease.
Soghra Bagheri, Ali A. Saboury, Thomas Haertlé, Mauro Rongioletti, Luciano Saso   +4 more
doaj   +1 more source

The Response of Cerebral Cortex to Haemorrhagic Damage: Experimental Evidence from a Penetrating Injury Model [PDF]

, 2015
Understanding the response of the brain to haemorrhagic damage is important in haemorrhagic stroke and increasingly in the understanding the cerebral degeneration and dementia that follow head trauma and head-impact sports.
Johnstone, Daniel M., Marotte, Lauren, Purushothuman, Sivaraman, Stone, Jonathan, Stowe, Sally   +4 more
core   +1 more source

APP processing in Alzheimer's disease

Molecular Brain, 2011
An important pathological feature of Alzheimer's disease (AD) is the presence of extracellular senile plaques in the brain. Senile plaques are composed of aggregations of small peptides called β-amyloid (Aβ).
Zhang Yun-wu, Thompson Robert, Zhang Han, Xu Huaxi   +3 more
doaj   +1 more source

Monoaminergic Neuropathology in Alzheimer's disease [PDF]

, 2017
Acknowledgments This work was supported by The Croatian Science Foundation grant. no. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Bažadona, Danira, Buée, Luc, Delalle, Ivana, Giovanni, Giuseppe Di, Harrington, Charles R., Hof, Patrick R., Jovanov-Milošević, Nataša, Leko, Mirjana Babić, Silva, Rohan de, Wischik, Claude M., Wray, Selina, Šimić, Goran   +11 more
core   +1 more source

CLU, CR1 and PICALM genes associate with Alzheimer's-related senile plaques

Alzheimer's Research & Therapy, 2011
IntroductionAPOE is the strongest risk gene for sporadic Alzheimer's disease (AD) so far. Recent genome wide association studies found links for sporadic AD with CLU and CR1 involved in Aβ clearance, and PICALM affecting intracellular trafficking ...
E. Kok, T. Luoto, S. Haikonen, S. Goebeler, H. Haapasalo, P. Karhunen   +5 more
semanticscholar   +1 more source

Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques

Acta Neuropathologica Communications, 2020
Massive deposition of amyloid β peptides (Aβ) as senile plaques (SP) characterizes the brain pathology of Alzheimer’s disease (AD). SPs exhibit a variety of morphologies, although little is known about the SP components that determine their morphology ...
Tadafumi Hashimoto, Daisuke Fujii, Yasushi Naka, Mayu Kashiwagi-Hakozaki, Yuko Matsuo, Yusuke Matsuura, Tomoko Wakabayashi, Takeshi Iwatsubo   +7 more
doaj   +1 more source

Glial Cell Extracellular Matrix in Alzheimer’s Disease [PDF]

, 1995
Many studies have yielded conflicting results regarding the toxicity of AB, the peptide which is the principal component of senile plaques in brains of patients with Alzheimer\u27s disease.
Canning, David R., DeWitt, David A, Perry, George   +2 more
core   +1 more source

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi, Yadi Fan, Qin Zhang, Yingying Huang, Mo Yang   +4 more
wiley   +1 more source