Results 51 to 60 of about 63,937 (247)
Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques
Acta Neuropathologica Communications, 2020 Massive deposition of amyloid β peptides (Aβ) as senile plaques (SP) characterizes the brain pathology of Alzheimer’s disease (AD). SPs exhibit a variety of morphologies, although little is known about the SP components that determine their morphology ...
Tadafumi Hashimoto +7 more
doaj +1 more source
Serum amyloid A inhibits astrocyte migration via activating p38 MAPK
Journal of Neuroinflammation, 2020 Background The accumulation of astrocytes around senile plaques is one of the pathological characteristics in Alzheimer’s disease (AD). Serum amyloid A (SAA), known as a major acute-phase protein, colocalizes with senile plaques in AD patients.
Aihua Lin +6 more
doaj +1 more source
Research progress on the pathogenesis of Alzheimer disease and microbes
Shanghai yufang yixue, 2023 Alzheimer disease （AD） is a progressive neurodegenerative disease that often occurs in the elderly. The main symptoms of AD patients are cognitive decline， especially memory deficits， communication problems， impaired performance of activities of daily ...
ZHA Yanan, WANG Feng, HAN Peipei
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Evidence of endothelial dysfunction in the development of Alzheimer's disease : Is Alzheimer's a vascular disorder? [PDF]
, 2013 Acknowledgements Dr Soiza is funded by an NRS Career Research Fellowship.
Kelleher, Rory J., Soiza, Roy L
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Chemistry – A European Journal, EarlyView.ABSTRACT ROS production due to Cu(amyloid‐β) redox cycling is proposed to contribute to the oxidative stress observed in Alzheimer's disease brains. We previously reported on a nitrogen and sulfur‐containing ligand, L, able to arrest Cu(Aβ)‐induced ROS production [Chem. Eur. J. 2023, 29,].
Marielle Drommi +4 more
wiley +1 more source
Herpes simplex virus interferes with amyloid precursor protein processing [PDF]
, 2005 Background The early events underlying Alzheimer's disease (AD) remain uncertain, although environmental factors may be involved. Work in this laboratory has shown that the combination of herpes simplex virus type 1 (HSV1) in brain and carriage of the
Dobson, C.B. +3 more
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ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi +6 more
wiley +1 more source
Journal of Pharmacological Sciences, 2012 Pathological hallmarks of Alzheimer’s disease (AD) include senile plaques, neurofibrillary tangles (NFTs), synaptic loss, and neurodegeneration. Senile plaques are composed of amyloid-β (Aβ) and are surrounded by microglia, a primary immune effector cell
Kazuyuki Takata, Yoshihisa Kitamura
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Cell Death and Disease, 2020 Alzheimer’s disease (AD) is the most common neurodegenerative disease with multifactorial pathologies including Aβ containing senile plaques and neurofibrillary tangles (NFT) consisted of aggregated Tau.
Zhourui Wu +3 more
doaj +1 more source
Imaging Studies of Aging, Neurodegenerative Disease, and Alcoholism. [PDF]
, 1995 Neurodegenerative diseases such as Alzheimers disease, disorders such as alcoholism, and the aging process can lead to impaired cognitive function and dementia.
Eberling, Jamie, JAGUST, William J
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