Results 81 to 90 of about 365,500 (282)
Altered Expression of the CB1 Cannabinoid Receptor in the Triple Transgenic Mouse Model of Alzheimer's Disease [PDF]
, 2014 The endocannabinoid system has gained much attention as a new potential pharmacotherapeutic target in various neurodegenerative diseases, including Alzheimer's disease (AD).
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Exploration, EarlyView.Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang +4 more
wiley +1 more source
The Degeneration of the Human Mind: An Analysis of Alzheimer’s Disease, A Kuhnian Perspective [PDF]
, 2013 In 1906, a German physician, Dr. Alois Alzheimer, specifically identified a collection of brain cell abnormalities (and the formation of plaque in the brain) as a disease, which forever changed the way scientists view degenerative cognitive disorders ...
Ilg, Genevieve
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Periodontitis, microbiomes and their role in Alzheimer’s disease [PDF]
, 2017 As far back as the eighteenth and early nineteenth centuries, microbial infections were responsible for vast numbers of deaths. The trend reversed with the introduction of antibiotics coinciding with longer life.
Crean, Stjohn +3 more
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Journal of Neuroscience, 1985 Senile (neuritic) plaques are one of the two major neuropathologic hallmarks of Alzheimer's disease. Despite their obvious importance (e.g., they are significantly correlated with severity of dementia), there is little present information about their ...
J. Rogers, J. Morrison
semanticscholar +1 more source
Mitochondrial dysfunction: Related diseases, influencing factors, and detection
Interdisciplinary Medicine, EarlyView.Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li +9 more
wiley +1 more source
Pathophysiology of Alzheimer’s Disease
Journal of Ardabil University of Medical Sciences, 2017 Alzheimer's disease (AD) is a common cause of dementia in elderly people that is accompanied by progressive cognitive decline and memory loss. The pathologic hallmarks of AD are synaptic and neuronal degeneration together with extracellular senile ...
Mohammad Amani
doaj
Frontiers in Aging Neuroscience, 2014 Pathological hallmarks indicative of Alzheimer’s disease, which are the plaques of Amyloid Beta 1-42 and neurofibrillary tangles, were found in brain of aged cynomolgus monkey.
Huda Shalahudin Darusman +12 more
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Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain. [PDF]
PLoS ONE, 2011 We applied a novel application of FLIM-FRET to in situ measurement and quantification of protein interactions to explore isoform specific differences in Aβ-ApoE interaction and ApoE tertiary conformation in senile plaques in human Alzheimer brain.
Phillip B Jones +9 more
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Morphology of neurofibrillary tangles and senile plaques
, 1990 Abnormal filaments (PHF) accumulate in neurons in Alzheimer’s disease in target areas. They fill the pericaryon but are also found in dendrites and axons. Their presence is associated with a disappearance of microtubules and neurofilaments, and an accumulation of dense bodies, altered mitochondria and smooth endoplasmic reticulum.
Flament Durand, Jacqueline +1 more
openaire +3 more sources