Results 121 to 130 of about 997,952 (298)
Advanced Science, EarlyView.The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen +15 more
wiley +1 more source
Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation
Advanced Science, EarlyView.VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang +15 more
wiley +1 more source
Natures Sciences SociétésL’interdisciplinarité ne se décrète pas a priori mais se construit progressivement, dans des interactions entre savoirs disciplinaires, pratiques interdisciplinaires et retours réflexifs. Mais comment apprendre l’interdisciplinarité ?
Cerceau Juliette +4 more
doaj +1 more source
La coopération selon le néoréalisme: la cooptation des petits États d'Europe centrale et de l'Est [PDF]
, 1995 Sens, Allen G.
core +1 more source
Advanced Science, EarlyView.Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song +12 more
wiley +1 more source
Le flottement grammatical et sémantique des noms bisyllabiques qui se terminent en -ež
Rasprave Instituta za Hrvatski Jezik i Jezikoslovlje, 2005 L’article traite la forme grammaticale aussi bien que la signification des noms bisyllabiques croates qui se terminent en -ež. On constate que dans des dictionnaires de la langue croate il y a une différence dans la description de ces noms du point de ...
Tomislava Bošnjak
doaj
Advanced Science, EarlyView.The m6A reader YTHDF1 drives intrahepatic cholangiocarcinoma (ICC) progression by remodeling the tumor immune microenvironment. YTHDF1 promotes MDSC recruitment via activation of m6A‐FOSL2‐CXCL6/CXCR2 axis, thereby suppressing CD8+ T cell infiltration and function.
Li Luo +14 more
wiley +1 more source
L’INTERPRÉTATION : UN PROBLÈME ÉPINEUX POUR LA TRADUCTION JURIDIQUE
Comparative Legilinguistics, 2019 Dans le contexte du tournant quantitatif amorcé dans le domaine de la traduction, tant pragmatique que juridique, le présent article vise à revenir sur le rôle des notions d'interprétation et de sens et à les replacer au centre des préoccupations de la ...
Margarete FLÖTER-DURR
doaj
Advanced Science, EarlyView.Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian +13 more
wiley +1 more source
Bilirubin as a Modulator of WNK1 Protein Signaling: Implications for Neuroinflammatory Diseases
Advanced Science, EarlyView.ABSTRACT Previously regarded merely as a potentially harmful waste product of heme catabolism, bilirubin has now emerged as a pleiotropic molecule with potent antioxidant, anti‐inflammatory, and hormone‐like properties. Recent findings have revealed protective effects against cardiovascular, metabolic, autoimmune, and neoplastic diseases, as well as ...
Sri Jayanti +3 more
wiley +1 more source