Results 191 to 200 of about 321,342 (308)

Clinical potential of fluid-based biomarkers for recurrent implantation failure: a systematic review. [PDF]

Front Endocrinol (Lausanne)
Moradi M, Santos LL, Zhou W, Menkhorst E, Dimitriadis E.   +4 more
europepmc   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Information Drives Sensory Perception and Willingness-to-Pay for Partially Dealcoholized Wine: Evidence from a Between-Subjects Experiment in Italy. [PDF]

Foods
Di Cosola F, Petrontino A, Tria E, Mattia S, Fanelli V, Montemurro C, Bozzo F.   +6 more
europepmc   +1 more source

Current Status and Challenges of Imaging-Based Diagnosis of Lymph Node Metastasis in Colon Cancer: The Lymph Node Committee of the Japanese Society for Cancer of the Colon and Rectum. [PDF]

Ann Gastroenterol Surg
This review of the status and challenges of diagnosis of lymph node metastasis in colon cancer suggests that it is currently difficult to establish strict criteria for lymph node metastasis, indicating only moderate diagnostic performance. ABSTRACT Background Accurate pre‐treatment evaluation of lymph node metastasis (LNM) in colon cancer is important ...
Ogawa S, Takayama Y, Takamizawa Y, Kanemitsu Y, Ueno H.   +4 more
europepmc   +2 more sources

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

Early Intervention Enrollment Among Substance-exposed Infants in Massachusetts: A Population-level Analysis. [PDF]

J Dev Behav Pediatr
Peacock-Chambers E, Gu KQ, Miller E, Shieh MS, Jurkowski BL, Palmer S, Diop H, Singh R, Litt JS, Leyenaar JK.   +9 more
europepmc   +1 more source

An Unbiased Geometry‐Resolved Membrane Platform for Proteome‐Scale Discovery of Membrane Curvature Sensors

Advanced Science, EarlyView.
A novel geometry‐resolved membrane platform provides a seamlessly integrated pipeline for studying curvature‐sensing proteins. By linking shotgun proteomics with quantitative imaging, this approach enables both the unbiased discovery and rigorous validation of novel sensors across the entire curvature range—positive, negative, and zero.
Takumi Komikawa, Rikuto Kawakami, Kunanon Chattrairat, Tatsuya Niwa, Taiga Ajiri, Takao Yasui, Masayoshi Tanaka   +6 more
wiley   +1 more source

Repositioning of Ertiprotafib via supramolecular assembly enables biomarker-guided therapy for acute kidney injury. [PDF]

J Nanobiotechnology
Jang H, Shin D, Park B, Lee JH, Ryu Y, Lee J, Ko E, Ko YS, Lee HY, Choi YE, Oh SW, Jo SK, Lee S, Park J, Kim K, Kim SH, Kim MG, Yang Y, Shim MK.   +18 more
europepmc   +1 more source

Sen

, 2011
[ES] Definición del término Sen en el diccionario Dicter.
openaire   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source