Results 161 to 170 of about 289,299 (297)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Sensation kinetics identifies novel bladder sensation-capacity curve shapes during urodynamics in patients with urinary urgency. [PDF]
Continence (Amst)Speich JE +9 more
europepmc +1 more source
From editorial board. A Sensation in the World of Tarkovsky Studies
, 2022 Nina Sputnitskaia, Maksim Kazyuchits
openalex +1 more source
Referred Sensation Areas in Bilateral Upper Limb Amputee
, 2023 Romulus Lontis, Winnie Jensen
openalex +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Effect of Moving Tactile Stimuli to Sole on Body Sway During Quiet Stance. [PDF]
Brain SciKawasaki T, Sawaguchi Y, Hiraoka K.
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Validation of the Japanese oral symptom assessment scale (OSAS-J) in patients with advanced cancer. [PDF]
Support Care CancerSena K, Ishiko R, Davies A, Koseki T.
europepmc +1 more source