Results 31 to 40 of about 112,278 (266)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Burning mouth syndrome: A review on its diagnostic and therapeutic approach

Journal of Pharmacy and Bioallied Sciences, 2014
Burning mouth syndrome (BMS), a chronic and intractable orofacial pain syndrome is characterized by the presence of burning sensation of the oral mucosa in the absence of specific oral lesion.
R Aravindhan, Santhanam Vidyalakshmi, Muniapillai Siva Kumar, C Satheesh, A Murali Balasubramanium, V Srinivas Prasad   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Genetic analyses of the bidirectional associations between common mental disorders and asthma

Frontiers in Psychiatry
ObjectiveAlthough extensive research has explored the link between mental disorders and asthma, the characteristics and patterns of this association are still unclear.
Zian Yan, Zian Yan, Jingjing Chen, Lijun Guo, Hongwei Zhang, Yanqiu Ding, Yanqiu Ding, Gaocan Ren, Yiyi Mao, Ruina Bai, Xiaochang Ma   +10 more
doaj   +1 more source

The Interplay of Cognitive Distortions, Impulsive Sensation Seeking, and Relapse Probability among Clients with Substance Use Disorders [PDF]

Tanta Scientific Nursing Journal
Background: Substance use disorders (SUDs) are characterized by chronic and recurrent patterns of substance abuse, often marked by high rates of relapse despite treatment.
Eslam Abdelhamid, Heba Hammad, Omima Morsy   +2 more
doaj   +1 more source

Evaluation of mast cells and burning sensation in various stages of Oral Submucous Fibrosis

Journal of Oral Biology and Craniofacial Research, 2020
Background: Oral Submucous Fibrosis (OSMF) is a potentially malignant disorder and burning sensation is the initial complaint among these patients. Scientific literature has established that mast cells play a major role in various inflammatory disorders.
Laliytha Bijai Kumar, Philips Mathew, Nirmal Madhavan, Sabin Siddique, Nandita Kshetrimayum, Kiran Iyer   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Taste disorders: A review

Journal of Indian Academy of Oral Medicine and Radiology, 2014
For maintenance of the health of an individual, taste sensation is very important. It is an important sensation that serves to assess the nutritious content of food, support oral intake, and prevent ingestion of potentially toxic substances. Disturbances
Vijay Kumar Ambaldhage, Jaishankar Homberhalli Puttabuddi, Purnachandrarao Naik Nunsavath, Yehoshuva R Tummuru   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source